Nestor P G, Faux S F, McCarley R W, Sands S F, Horvath T B, Peterson A
Department of Psychiatry, Harvard Medical School, Brockton VA Medical Center, MA.
Neuropsychopharmacology. 1991 Feb;4(2):145-9.
To test the hypothesis that antipsychotic drugs improve attentional processes in schizophrenia, we used a computer-controlled, perceptually degraded continuous performance test (CPT), based on signal detection theory. CPT stimuli were degraded (blurred) to reduce discriminability so that signal detection analysis could be used to distinguish specific attentional processes, as measured by A', from nonspecific factors, as measured by B". Thirteen medicated and 12 neuroleptic-withdrawn schizophrenics visually monitored digits to detect a target under perceptually undegraded and degraded conditions. The principal result was that the neuroleptic-withdrawn patients showed a significant decline in the attention-specific measure of A' over time on task only for the degraded targets, independent of changes in the nonspecific index of B". These results demonstrate that neuroleptic withdrawal may compromise specific attentional processes, namely the ability to sustain attention, as measured by a precise performance task which controlled for nonspecific factors.
为了检验抗精神病药物能改善精神分裂症患者注意力过程这一假设，我们采用了一种基于信号检测理论、由计算机控制的、感知觉退化的连续性能测试（CPT）。CPT刺激被退化（模糊化）以降低可辨别性，这样信号检测分析就能用于区分由A'测量的特定注意力过程和由B''测量的非特定因素。13名正在服药的精神分裂症患者和12名停用抗精神病药物的精神分裂症患者在感知觉未退化和退化的条件下，通过视觉监测数字来检测目标。主要结果是，仅对于退化目标，停用抗精神病药物的患者在任务进行过程中，其注意力特定测量指标A'随时间显著下降，且与非特定指标B''的变化无关。这些结果表明，停用抗精神病药物可能会损害特定的注意力过程，即通过控制非特定因素的精确性能任务所测量的持续注意力能力。
