Liu S K, Chen W J, Chang C J, Lin H N
Department of Psychiatry, College of Medicine, National Taiwan University, Taipei.
Neuropsychopharmacology. 2000 Mar;22(3):311-9. doi: 10.1016/S0893-133X(99)00137-2.
To help determine whether sustained attention deficits as measured with the Continuous Performance Test (CPT) are stable vulnerability indicators of schizophrenia, we compared the CPT performance of schizophrenic patients before and after treatment with risperidone or haloperidol. In this double blind trial, 56 schizophrenic patients were randomly assigned to a 12-week regimen of either risperidone or haloperidol, after a 1-week washout period. The patients undertook two sessions of the CPT (undegraded and 25% degraded) twice, one at the end of the washout period and the other at the end of the study. Thirty-eight patients completed the study, 19 in each group. Both groups experienced significant improvements in clinical symptoms, and the risperidone group showed no change in the severity of extrapyramidal symptoms. Despite those improvements, the CPT performance indexes did not change significantly from the beginning to the end of the study. These findings indicate that sustained attention deficits might be stable vulnerability indicators of schizophrenia.
为了帮助确定用连续性能测试（CPT）测量的持续性注意力缺陷是否是精神分裂症的稳定易感性指标，我们比较了使用利培酮或氟哌啶醇治疗前后精神分裂症患者的CPT表现。在这项双盲试验中，56名精神分裂症患者在经过1周的洗脱期后，被随机分配到接受利培酮或氟哌啶醇的12周治疗方案中。患者进行了两次CPT测试（未降级和25%降级），一次在洗脱期结束时，另一次在研究结束时。38名患者完成了研究，每组19名。两组患者的临床症状均有显著改善，利培酮组的锥体外系症状严重程度没有变化。尽管有这些改善，但从研究开始到结束，CPT表现指标没有显著变化。这些发现表明，持续性注意力缺陷可能是精神分裂症的稳定易感性指标。
