Armstrong D, Cameron R G
Department of Pathology, University of Toronto, Ontario, Canada.
Cancer Lett. 1991 May 1;57(2):153-7. doi: 10.1016/0304-3835(91)90209-z.
The neoplastic responses of liver to prolonged continuous exposures of deoxycholic acid (DCA) in the diet with or without prior initiation was examined in Fischer 344 (F-344) and Sprague-Dawley (SD) male rats. In both rat strains, 7 months of continuous feeding of 0.5% (F-344 rats) or 1.0% (SD rats) of deoxycholic acid in chow diet generated hepatic nodules which persisted up to 8 months after deoxycholic acid was stopped. In one group of Sprague-Dawley male rats, 7 months of deoxycholic acid was preceded by an initiating dose of diethylnitrosamine. In 10 out of 15 of these rats, not only persistent nodules but also 26 liver cancers (large, multifocal, invasive, lung metastases) become evident by 8 months after cessation of deoxycholic acid.
在Fischer 344（F-344）和Sprague-Dawley（SD）雄性大鼠中，研究了肝脏对饮食中长时间持续暴露于脱氧胆酸（DCA）的肿瘤反应，无论是否有预先启动。在这两种大鼠品系中，在普通饮食中连续7个月喂食0.5%（F-344大鼠）或1.0%（SD大鼠）的脱氧胆酸会产生肝结节，在停止喂食脱氧胆酸后，这些结节持续长达8个月。在一组Sprague-Dawley雄性大鼠中，在给予脱氧胆酸7个月之前，先给予启动剂量的二乙基亚硝胺。在这些大鼠中的15只中有10只，在停止喂食脱氧胆酸8个月后，不仅出现了持续的结节，还出现了26例肝癌（大的、多灶性的、侵袭性的、肺转移）。
