Tapp Robyn J, Dunstan David W, Phillips Pat, Tonkin Andrew, Zimmet Paul Z, Shaw Jonathan E
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
Diabetes Res Clin Pract. 2006 Nov;74(2):154-61. doi: 10.1016/j.diabres.2006.03.012. Epub 2006 Jun 5.
We examined the association of quality of life with glucose tolerance status in an Australian population to determine the stage in the development of diabetes that quality of life is impaired.
The Australian Diabetes, Obesity and Lifestyle study (AusDiab) was a population-based study of 11,247 people from randomly selected areas of Australia. As part of the study, participants underwent an oral glucose tolerance test and completed the SF-36 quality of life questionnaire.
Previously diagnosed diabetes was associated with a significantly greater risk of being in the lowest quartile of each dimension of the SF-36 scale (except for mental health) and this association was only partially attenuated by adjustment for age, sex, body mass index (BMI), physical activity and treatment for hypertension and lipid abnormalities (adjusted odds ratios [95% CI]: bodily pain, 1.51 [1.18-1.94]; general health, 2.20 [1.64-2.95]; physical functioning, 1.50 [1.10-2.05]; role limitation (emotional), 1.43 [1.07-1.91]; role limitation (physical), 1.57 [1.13-2.18]; social functioning, 1.93 [1.46-2.54] and vitality, 2.24 [1.56-3.22]. Among those with newly diagnosed diabetes (NDM) and impaired glucose tolerance (IGT), there was also evidence of reduced quality of life on some dimensions of the SF-36 scale (NDM, general health, physical functioning and role limitation (physical); IGT, physical functioning and social functioning) after adjustment for confounders.
These findings show that diabetes is associated with a reduced quality of life and that this is evident in the early stage of the disease, particularly in relation to the ability to perform physical activities.
我们在澳大利亚人群中研究了生活质量与葡萄糖耐量状态之间的关联，以确定生活质量受损发生在糖尿病发展的哪个阶段。
澳大利亚糖尿病、肥胖与生活方式研究（AusDiab）是一项基于人群的研究，研究对象为来自澳大利亚随机选定地区的11247人。作为研究的一部分，参与者接受了口服葡萄糖耐量测试，并完成了SF - 36生活质量问卷。
先前诊断出的糖尿病与SF - 36量表各维度（心理健康维度除外）处于最低四分位数的风险显著增加相关，并且在对年龄、性别、体重指数（BMI）、身体活动以及高血压和血脂异常治疗进行调整后，这种关联仅部分减弱（调整后的比值比[95%置信区间]：身体疼痛，1.51[1.18 - 1.94]；总体健康，2.20[1.64 - 2.95]；身体功能，1.50[1.10 - 2.05]；角色受限（情感方面），1.43[1.07 - 1.91]；角色受限（身体方面），1.57[1.13 - 2.18]；社会功能，1.93[1.46 - 2.54]；活力，2.24[1.56 - 3.22]）。在新诊断出糖尿病（NDM）和葡萄糖耐量受损（IGT）的人群中，在对混杂因素进行调整后，也有证据表明SF - 36量表某些维度的生活质量有所下降（NDM，总体健康、身体功能和角色受限（身体方面）；IGT，身体功能和社会功能）。
这些发现表明糖尿病与生活质量降低相关，并且在疾病早期就很明显，特别是在进行身体活动的能力方面。
