星形胶质细胞中一氧化氮合酶诱导的信号
Signals for the induction of nitric oxide synthase in astrocytes.
作者信息
Saha Ramendra N, Pahan Kalipada
机构信息
Section of Neuroscience, Department of Oral Biology, University of Nebraska Medical Center College of Dentistry, 40th and Holdrege, Lincoln, NE 68583, United States.
出版信息
Neurochem Int. 2006 Jul;49(2):154-63. doi: 10.1016/j.neuint.2006.04.007. Epub 2006 Jun 5.
Abstract
Nitric oxide (NO), being a double-edged sword depending on its concentration in the microenvironment, is involved in both physiological and pathological processes of many organ systems including brain and spinal cord. It is now well-documented that once inducible nitric oxide synthase (iNOS) is expressed in CNS in a signal-dependent fashion, NO in excess of physiological thresholds is produced and this excess NO then plays a role in the pathogenesis of stroke, demyelination and other neurodegenerative diseases. Therefore, a keen interest has been generated in recent years in comprehending the regulation of this enzyme in brain cells. The present review summarizes our current understanding of signaling mechanisms leading to transcription of the iNOS gene in activated astrocytes. We attempt this comprehension with a hope to identify potential targets to intervene NO-mediated CNS disorders.
摘要
一氧化氮（NO）根据其在微环境中的浓度扮演着双刃剑的角色，参与包括脑和脊髓在内的许多器官系统的生理和病理过程。现在有充分的文献记载，一旦诱导型一氧化氮合酶（iNOS）以信号依赖的方式在中枢神经系统中表达，就会产生超过生理阈值的NO，而这种过量的NO随后在中风、脱髓鞘和其他神经退行性疾病的发病机制中发挥作用。因此，近年来人们对理解这种酶在脑细胞中的调节产生了浓厚的兴趣。本综述总结了我们目前对激活的星形胶质细胞中导致iNOS基因转录的信号机制的理解。我们尝试进行这种理解，希望能确定干预NO介导的中枢神经系统疾病的潜在靶点。
相似文献
1
Signals for the induction of nitric oxide synthase in astrocytes.星形胶质细胞中一氧化氮合酶诱导的信号
Neurochem Int. 2006 Jul;49(2):154-63. doi: 10.1016/j.neuint.2006.04.007. Epub 2006 Jun 5.
2
Inducible nitric oxide synthase in the central nervous system.中枢神经系统中的诱导型一氧化氮合酶。
J Mol Neurosci. 1994;5(4):219-29. doi: 10.1007/BF02736723.
3
Inverse regulation of inducible nitric oxide synthase (iNOS) and arginase I by the protein tyrosine phosphatase SHP-1 in CNS glia.中枢神经系统胶质细胞中蛋白酪氨酸磷酸酶SHP-1对诱导型一氧化氮合酶（iNOS）和精氨酸酶I的反向调节
Glia. 2006 Jun;53(8):827-35. doi: 10.1002/glia.20344.
4
Inhibitors of protein phosphatase 1 and 2A differentially regulate the expression of inducible nitric-oxide synthase in rat astrocytes and macrophages.蛋白磷酸酶1和2A的抑制剂对大鼠星形胶质细胞和巨噬细胞中诱导型一氧化氮合酶的表达有不同的调节作用。
J Biol Chem. 1998 May 15;273(20):12219-26. doi: 10.1074/jbc.273.20.12219.
5
Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms.调节诱导型一氧化氮合酶的药理学策略：神经退行性与神经保护机制
Neurochem Int. 2006 Jul;49(2):170-82. doi: 10.1016/j.neuint.2006.04.010. Epub 2006 Jun 12.
6
Nitric oxide production by endothelin-1 enhances astrocytic migration via the tyrosine nitration of matrix metalloproteinase-9.内皮素-1 产生的一氧化氮通过基质金属蛋白酶-9 的酪氨酸硝化增强星形胶质细胞迁移。
J Cell Physiol. 2011 Sep;226(9):2244-56. doi: 10.1002/jcp.22560.
7
TAK1-mediated induction of nitric oxide synthase gene expression in glial cells.TAK1介导的神经胶质细胞中一氧化氮合酶基因表达的诱导。
J Neurochem. 2003 Oct;87(1):238-47. doi: 10.1046/j.1471-4159.2003.01998.x.
8
Regulation of inducible nitric oxide synthase in proinflammatory cytokine-stimulated human primary astrocytes.促炎细胞因子刺激的人原代星形胶质细胞中诱导型一氧化氮合酶的调控
Free Radic Biol Med. 2005 Mar 1;38(5):655-64. doi: 10.1016/j.freeradbiomed.2004.11.021.
9
Estrogen regulation of nitric oxide and inducible nitric oxide synthase (iNOS) in immune cells: implications for immunity, autoimmune diseases, and apoptosis.雌激素对免疫细胞中一氧化氮及诱导型一氧化氮合酶（iNOS）的调节作用：对免疫、自身免疫性疾病及细胞凋亡的影响
Nitric Oxide. 2006 Nov;15(3):177-86. doi: 10.1016/j.niox.2006.03.009. Epub 2006 May 2.
10
Multiple inhibitory pathways for lipopolysaccharide- and pro-inflammatory cytokine-induced nitric oxide production in cultured astrocytes.培养的星形胶质细胞中脂多糖和促炎细胞因子诱导一氧化氮产生的多种抑制途径。
Neuroscience. 2007 Feb 9;144(3):911-9. doi: 10.1016/j.neuroscience.2006.10.040. Epub 2006 Dec 6.
引用本文的文献
1
Astrocyte-mediated inflammatory responses in traumatic brain injury: mechanisms and potential interventions.创伤性脑损伤中星形胶质细胞介导的炎症反应：机制与潜在干预措施
Front Immunol. 2025 May 8;16:1584577. doi: 10.3389/fimmu.2025.1584577. eCollection 2025.
2
Astrocytic spermidine insufficiency contributes to enhanced pain sensitivity associated with ApoE4.星形胶质细胞的亚精胺不足导致与载脂蛋白E4相关的疼痛敏感性增强。
J Headache Pain. 2025 May 15;26(1):116. doi: 10.1186/s10194-025-02054-8.
3
Build muscles and protect myelin.增强肌肉并保护髓磷脂。
NeuroImmune Pharm Ther. 2024 Oct 16;3(3-4):175-182. doi: 10.1515/nipt-2024-0015. eCollection 2024 Sep.
4
Induction of Neural Differentiation and Protection by a Novel Slow-Release Nanoparticle Estrogen Construct in a Rat Model of Spinal Cord Injury.新型缓释纳米雌激素构建体在大鼠脊髓损伤模型中的神经诱导分化和保护作用。
Neurochem Res. 2024 Nov 30;50(1):41. doi: 10.1007/s11064-024-04289-4.
5
Control of astrocytic Ca signaling by nitric oxide-dependent S-nitrosylation of Ca homeostasis modulator 1 channels.一氧化氮依赖的 Ca 稳态调节剂 1 通道 S-亚硝化作用对星形胶质细胞 Ca 信号的调控。
Biol Res. 2024 Apr 30;57(1):19. doi: 10.1186/s40659-024-00503-3.
6
Quinic Acid Alleviates Behavior Impairment by Reducing Neuroinflammation and MAPK Activation in LPS-Treated Mice.奎尼酸通过减轻脂多糖处理小鼠的神经炎症和丝裂原活化蛋白激酶激活来缓解行为损伤。
Biomol Ther (Seoul). 2024 May 1;32(3):309-318. doi: 10.4062/biomolther.2023.184. Epub 2024 Apr 9.
7
Crosstalk between Oxidative Stress and Inflammation Caused by Noise and Air Pollution-Implications for Neurodegenerative Diseases.噪声与空气污染所致氧化应激和炎症之间的相互作用——对神经退行性疾病的影响
Antioxidants (Basel). 2024 Feb 22;13(3):266. doi: 10.3390/antiox13030266.
8
Nebulization of low-dose aspirin ameliorates Huntington's pathology in N171-82Q transgenic mice.低剂量阿司匹林雾化吸入可改善N171-82Q转基因小鼠的亨廷顿氏病理症状。
NeuroImmune Pharm Ther. 2024 Feb 9;3(1):47-59. doi: 10.1515/nipt-2023-0026. eCollection 2024 Mar.
9
Cinnamic acid, a natural plant compound, exhibits neuroprotection in a mouse model of Sandhoff disease via PPARα.肉桂酸是一种天然植物化合物，通过过氧化物酶体增殖物激活受体α（PPARα）在桑德霍夫病小鼠模型中发挥神经保护作用。
NeuroImmune Pharm Ther. 2024 Mar 15;3(1):17-32. doi: 10.1515/nipt-2023-0027. eCollection 2024 Mar.
10
Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches.针对记忆丧失的阿司匹林治疗：未来治疗方法的分子机制视角。
Inflammopharmacology. 2023 Dec;31(6):2827-2842. doi: 10.1007/s10787-023-01347-1. Epub 2023 Nov 4.
本文引用的文献
1
A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail.一个关于SHP的故事：C末端尾巴对SHP-1和SHP-2酪氨酸磷酸酶调节的观点
Cell Signal. 2005 Nov;17(11):1323-32. doi: 10.1016/j.cellsig.2005.05.016.
2
Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes.双链RNA在表达Toll样受体3（TLR3）的星形胶质细胞中引发抗病毒和炎症反应程序以及谷氨酸转运功能障碍。
Glia. 2005 Nov 1;52(2):153-62. doi: 10.1002/glia.20234.
3
Astrocyte activation and reactive gliosis.星形胶质细胞激活与反应性胶质增生。
Glia. 2005 Jun;50(4):427-434. doi: 10.1002/glia.20207.
4
Glial nitric oxide and ischemia.神经胶质细胞一氧化氮与缺血
Glia. 2005 Jun;50(4):417-426. doi: 10.1002/glia.20143.
5
Phosphoinositide 3-kinase in disease: timing, location, and scaffolding.疾病中的磷脂酰肌醇3激酶：时机、定位与支架作用
Curr Opin Cell Biol. 2005 Apr;17(2):141-9. doi: 10.1016/j.ceb.2005.02.011.
6
Role of MAPK/ERK1/2 in the glucose deprivation-induced death in immunostimulated astroglia.丝裂原活化蛋白激酶/细胞外信号调节激酶1/2（MAPK/ERK1/2）在免疫刺激的星形胶质细胞中葡萄糖剥夺诱导的死亡中的作用
Neurosci Lett. 2005 Mar 16;376(3):171-6. doi: 10.1016/j.neulet.2004.11.077. Epub 2004 Dec 19.
7
Knock your SOCS off!把你的细胞因子信号转导抑制蛋白敲除掉！
J Clin Invest. 2005 Feb;115(2):233-6. doi: 10.1172/JCI24228.
8
Regulation of inducible nitric oxide synthase in proinflammatory cytokine-stimulated human primary astrocytes.促炎细胞因子刺激的人原代星形胶质细胞中诱导型一氧化氮合酶的调控
Free Radic Biol Med. 2005 Mar 1;38(5):655-64. doi: 10.1016/j.freeradbiomed.2004.11.021.
9
Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability.环磷酸腺苷（cAMP）在神经胶质细胞和巨噬细胞诱导型一氧化氮合酶（iNOS）表达中的双重作用是由p38丝裂原活化蛋白激酶（p38-MAPK）/活化转录因子2（ATF-2）激活的差异调节和iNOS稳定性介导的。
Free Radic Biol Med. 2004 Dec 1;37(11):1834-44. doi: 10.1016/j.freeradbiomed.2004.08.017.
10
The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma.15-脱氧-Δ12,14-前列腺素J2通过下调磷脂酰肌醇3-激酶-Akt-NF-κB-p300途径中的多个步骤来抑制原代大鼠星形胶质细胞中的炎症反应，该过程独立于过氧化物酶体增殖物激活受体γ。
J Immunol. 2004 Oct 15;173(8):5196-208. doi: 10.4049/jimmunol.173.8.5196.
Zotero 插件