Zappasodi Filippo, Pasqualetti Patrizio, Tombini Mario, Ercolani Matilde, Pizzella Vittorio, Rossini Paolo M, Tecchio Franca
ISTC-CNR, Roma, Italy.
Clin Neurophysiol. 2006 Jul;117(7):1518-28. doi: 10.1016/j.clinph.2006.03.016. Epub 2006 Jun 5.
To characterize the age- and gender- dependence of sensory hand cortical representation in the two hemispheres in healthy population.
In 57 adults, the cerebral activity from rolandic areas as detected by magnetoencephalography was considered both in a resting state (spectral power properties) and in response to the electrical stimulation of the contralateral median nerve (M20 and M30 cortical sources).
We found a dependence of rest and evoked activity on age (alpha rhythm slowing, high frequency power increase, M20 latency increase, M20 strength increase, no change in M30) and on gender (higher alpha frequency, higher beta power, higher spectral entropy, lower M20 amplitude in women). These changes were quite symmetrical in the two hemispheres, making the interhemispheric differences non-dependent on age and gender. Moreover, lower total power and faster alpha rhythm appeared in the dominant hemisphere.
Age and gender have a significant effect on spontaneous and evoked activity at the primary sensorimotor cortex.
The results consolidate the reference base in healthy population, to study pathological conditions. Inter-hemispheric asymmetries are confirmed as a sensitive indicator for the early identification of possible neuronal rearrangements due to unilateral brain injuries.
描述健康人群中两个半球手部感觉皮层代表区的年龄和性别依赖性。
对57名成年人，通过脑磁图检测罗兰区的大脑活动，分别在静息状态（频谱功率特性）和对侧正中神经电刺激时（M20和M30皮层源）进行观察。
我们发现静息和诱发活动依赖于年龄（α节律减慢、高频功率增加、M20潜伏期增加、M20强度增加、M30无变化）和性别（女性α频率更高、β功率更高、频谱熵更高、M20振幅更低）。这些变化在两个半球相当对称，使得半球间差异不依赖于年龄和性别。此外，优势半球的总功率更低，α节律更快。
年龄和性别对初级感觉运动皮层的自发和诱发活动有显著影响。
这些结果巩固了健康人群的参考基础，以研究病理状况。半球间不对称被确认为早期识别由于单侧脑损伤可能导致的神经元重排的敏感指标。
