Candelaria-Cook Felicha T, Solis Isabel, Schendel Megan E, Wang Yu-Ping, Wilson Tony W, Calhoun Vince D, Stephen Julia M
The Mind Research Network, a Division of Lovelace Biomedical Research Institute, 1101 Yale Blvd NE, Albuquerque, NM 87106, United States.
Department of Psychology, University of New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, United States.
Cereb Cortex. 2022 Nov 21;32(23):5404-5419. doi: 10.1093/cercor/bhac023.
Neural oscillations may be sensitive to aspects of brain maturation such as myelination and synaptic density changes. Better characterization of developmental trajectories and reliability is necessary for understanding typical and atypical neurodevelopment. Here, we examined reliability in 110 typically developing children and adolescents (aged 9-17 years) across 2.25 years. From 10 min of magnetoencephalography resting-state data, normalized source spectral power and intraclass correlation coefficients were calculated. We found sex-specific differences in global normalized power, with males showing age-related decreases in delta and theta, along with age-related increases in beta and gamma. Females had fewer significant age-related changes. Structural magnetic resonance imaging revealed that males had more total gray, subcortical gray, and cortical white matter volume. There were significant age-related changes in total gray matter volume with sex-specific and frequency-specific correlations to normalized power. In males, increased total gray matter volume correlated with increased theta and alpha, along with decreased gamma. Split-half reliability was excellent in all frequency bands and source regions. Test-retest reliability ranged from good (alpha) to fair (theta) to poor (remaining bands). While resting-state neural oscillations can have fingerprint-like quality in adults, we show here that neural oscillations continue to evolve in children and adolescents due to brain maturation and neurodevelopmental change.
神经振荡可能对大脑成熟的某些方面敏感，如髓鞘形成和突触密度变化。为了理解典型和非典型神经发育，更好地刻画发育轨迹和可靠性是必要的。在此，我们在2.25年的时间里对110名发育正常的儿童和青少年（9至17岁）的可靠性进行了研究。从10分钟的脑磁图静息态数据中，计算了归一化源谱功率和组内相关系数。我们发现，在全局归一化功率方面存在性别差异，男性的δ波和θ波随年龄增长而降低，β波和γ波随年龄增长而升高。女性与年龄相关的显著变化较少。结构磁共振成像显示，男性的全脑灰质、皮质下灰质和皮质白质体积更大。全脑灰质体积存在显著的年龄相关变化，且与归一化功率存在性别特异性和频率特异性的相关性。在男性中，全脑灰质体积增加与θ波和α波增加以及γ波降低相关。在所有频段和源区域，分半信度都非常好。重测信度从良好（α波）到中等（θ波）再到较差（其余频段）不等。虽然静息态神经振荡在成年人中可能具有指纹般的特征，但我们在此表明，由于大脑成熟和神经发育变化，神经振荡在儿童和青少年中仍在不断演变。
