Ozgocmen Salih, Yoldas Tahir, Yigiter Remzi, Kaya Arzu, Ardicoglu Ozge
Department of Physical Medicine and Rehabilitation, Elazig, Turkey.
Arch Med Res. 2006 Jul;37(5):630-4. doi: 10.1016/j.arcmed.2005.11.008.
This study proposed to assess the autonomic nervous system (ANS) functions in fibromyalgia (FM) by using two electrophysiological tests, sympathetic skin response (SSR) and the heart rate variability named R-R interval variation (RRIV).
Sympathetic skin response and RRIV were studied in 29 female patients with FM and 22 healthy age-matched female controls. R-R interval variation at rest (R%), during deep breathing (D%), the difference between D% and R% (D-R) and the ratio of D-R% (D/R) were determined. Pain threshold was measured using a mechanical algometer.
R-R interval variation at rest (R%) and D/R did not show significant difference between patients and controls, whereas D% and D-R were significantly lower in patients compared to controls. SSR latencies of patients' hands and feet had no significant difference compared to controls' hand and feet SSR latencies. SSR latencies of patients' hands correlated significantly with control point score, total myalgic score, Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating Scale. Sympathetic skin response latencies of patients' feet correlated only with HARS.
Analysis of heart rate variability may be useful and complementary to clinical examination in patients with symptoms of dysfunction in cardiovascular reflex pathways.
本研究旨在通过两项电生理测试，即交感皮肤反应（SSR）和心率变异性（称为R-R间期变异，RRIV）来评估纤维肌痛（FM）患者的自主神经系统（ANS）功能。
对29名女性纤维肌痛患者和22名年龄匹配的健康女性对照者进行交感皮肤反应和RRIV研究。测定静息时的R-R间期变异（R%）、深呼吸时的R-R间期变异（D%）、D%与R%的差值（D-R）以及D-R%的比值（D/R）。使用机械压力觉计测量疼痛阈值。
患者与对照组静息时的R-R间期变异（R%）和D/R无显著差异，而患者的D%和D-R显著低于对照组。患者手部和足部的SSR潜伏期与对照组手部和足部的SSR潜伏期无显著差异。患者手部的SSR潜伏期与压痛点评分、总肌痛评分、汉密尔顿焦虑量表（HARS）和汉密尔顿抑郁量表显著相关。患者足部的交感皮肤反应潜伏期仅与HARS相关。
对于有心血管反射通路功能障碍症状的患者，心率变异性分析可能有助于临床检查并起到补充作用。
