对“热量限制通过HST2介导不依赖SIR2的寿命延长”的评论
Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction".
作者信息
Kaeberlein Matt, Steffen Kristan K, Hu Di, Dang Nick, Kerr Emily O, Tsuchiya Mitsuhiro, Fields Stanley, Kennedy Brian K
机构信息
Department of Pathology, University of Washington, Seattle, WA 98195, USA.
出版信息
Science. 2006 Jun 2;312(5778):1312; author reply 1312. doi: 10.1126/science.1124608.
Calorie restriction (CR) increases life span in yeast independently of Sir2. Lamming et al. (Reports, 16 September 2005, p. 1861) recently proposed that Sir2-independent life-span extension by CR is mediated by the Sir2 paralogs Hst1 and Hst2. Contradictory to this, we find that CR greatly increases life span in cells lacking Sir2, Hst1, and Hst2, which suggests that CR is not mediated by Sir2, Hst2, or Hst1.
热量限制（CR）在不依赖Sir2的情况下延长酵母的寿命。Lamming等人（《科学》，2005年9月16日，第1861页）最近提出，CR不依赖Sir2的寿命延长是由Sir2旁系同源物Hst1和Hst2介导的。与此相反，我们发现CR在缺乏Sir2、Hst1和Hst2的细胞中极大地延长了寿命，这表明CR不是由Sir2、Hst2或Hst1介导的。
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