Maghnie M, Valtorta A, Moretta A, Larizza D, Girani M A, Severi F
Department of Paediatrics, University of Pavia, IRCCS Policlinico S. Matteo, Italy.
Eur J Pediatr. 1991 Feb;150(4):238-41. doi: 10.1007/BF01955520.
To delineate the effects of human chorionic gonadotropin (hCG) administration on immune responsiveness, immunological parameters including serum immunoglobulins, total and differential white blood cell count T and B lymphocyte membrane phenotype, in vitro, proliferative response to phytohaemagglutinin, Concanavalin A (ConA) and pokeweed mitogen were studied in 13 prepubertal cryptorchid boys before, during, and 3 months after hCG therapy. Before treatment, all the immunological parameters were normal except for an unexpected high percentage of T suppressor-cytotoxic cells (CD8+). During therapy, the absolute number of total peripheral blood lymphocytes, and that of total T-cells, T helper-inducer cells and of CD8+ subsets were diminished. The percentage of CD8+ cells and lymphocyte response to ConA decreased significantly and returned to normal after hCG withdrawal. The possible effects of long-term hCG treatment remain to be determined.
为了描述人绒毛膜促性腺激素（hCG）给药对免疫反应性的影响，我们对13名青春期前隐睾男孩在hCG治疗前、治疗期间和治疗后3个月的免疫参数进行了研究，这些参数包括血清免疫球蛋白、白细胞总数和分类计数、T和B淋巴细胞膜表型、体外对植物血凝素、刀豆蛋白A（ConA）和商陆有丝分裂原的增殖反应。治疗前，除了意外出现的高比例T抑制细胞毒性细胞（CD8+）外，所有免疫参数均正常。治疗期间，外周血淋巴细胞总数、总T细胞、T辅助诱导细胞和CD8+亚群的绝对数量减少。CD8+细胞百分比和淋巴细胞对ConA的反应显著降低，hCG停药后恢复正常。长期hCG治疗的可能影响仍有待确定。
