Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, W. 1, Department of Biochemistry, University College London, Gower Street, London, W. 1, and Department of Medicine, University of California, Los Angeles, Calif. 90024, U.S.A.
Biochem J. 1967 Dec;105(3):1013-8. doi: 10.1042/bj1051013.
The concentrations of the oxidized and reduced forms of the nicotinamide nucleotides were measured in the epididymal fat pads of normal, alloxan-diabetic and hypophysectomized rats. In both alloxan-diabetic rats and hypophysectomized rats the weight of the adipose tissue fell, as did the total content of NADH and NADPH; in addition, NAD(+) was decreased in the alloxan-diabetic group. Of these changes the most marked was in NADPH and this was the only significant difference when the results were expressed as nicotinamide nucleotides/mg. of tissue protein. The concentration of NADPH in the hypophysectomized rats was not altered by treatment with growth hormone but was restored to normal by treatment with thyroxine. These results are discussed in relation to the known effect of these hormonal conditions on lipid synthesis in adipose tissue.
我们测量了正常、链脲佐菌素糖尿病和垂体切除大鼠附睾脂肪垫中烟酰胺核苷酸的氧化和还原形式的浓度。在链脲佐菌素糖尿病大鼠和垂体切除大鼠中，脂肪组织的重量下降，NADH 和 NADPH 的总量也下降；此外，糖尿病组的 NAD(+)减少。在这些变化中，最明显的是 NADPH，当结果以烟酰胺核苷酸/组织蛋白毫克表示时，这是唯一的显著差异。生长激素处理并未改变垂体切除大鼠 NADPH 的浓度，但甲状腺素处理使其恢复正常。这些结果与这些激素条件对脂肪组织中脂质合成的已知影响有关。
