Wilkinson N, Hasleton P S, Wilkes S, Quigley A
Department of Pathology, Wythenshawe Hospital, Manchester.
J Clin Pathol. 1991 Apr;44(4):343. doi: 10.1136/jcp.44.4.343.
To determine if amplification of the C-erb-B2 proto-oncogene could be correlated with prognosis in carcinoid tumours, 49 pulmonary carcinoid tumours (26 typical, 23 atypical) were examined using a polyclonal antibody to the C-terminal peptide of the C-erb-B2 protein sequence. No C-erb-B2 gene product could be shown: the demonstration of C-erb-B2 does not seem to help, therefore, in determining diagnosis or prognosis in pulmonary carcinoid tumours.
为了确定C-erb-B2原癌基因的扩增是否与类癌肿瘤的预后相关，我们使用针对C-erb-B2蛋白序列C末端肽的多克隆抗体对49例肺类癌肿瘤（26例典型类癌，23例非典型类癌）进行了检测。未发现C-erb-B2基因产物：因此，C-erb-B2的检测似乎无助于肺类癌肿瘤的诊断或预后判断。
