二氯乙酸对灌流大鼠心脏丙酮酸脱氢酶的激活（简短通讯）。
Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication).
机构信息
Department of Biochemistry, Medical School, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
出版信息
Biochem J. 1973 Jun;134(2):651-3. doi: 10.1042/bj1340651.
Abstract
The activity of pyruvate dehydrogenase was assayed in extracts of rat hearts perfused in vitro with media containing glucose and insulin+/-acetate+/-dichloroacetate. Dichloroacetate (100mum, 1mm or 10mm) increased the activity of pyruvate dehydrogenase in perfusions with glucose or glucose+acetate. Evidence is given that dichloroacetate may facilitate the conversion of pyruvate dehydrogenase from an inactive (phosphorylated) form into an active (dephosphorylated) form.
摘要
用含有葡萄糖和胰岛素+/-醋酸盐+/-双氯醋酸盐的介质体外灌流大鼠心脏提取液，测定丙酮酸脱氢酶的活性。双氯醋酸盐（100mum、1mm 或 10mm）增加了葡萄糖或葡萄糖+醋酸盐灌流中丙酮酸脱氢酶的活性。有证据表明，双氯醋酸盐可以促进丙酮酸脱氢酶从无活性（磷酸化）形式转化为有活性（去磷酸化）形式。
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Hypoglycaemic action of diisopropyl-ammonium salts in experimental diabetes.二异丙铵盐在实验性糖尿病中的降血糖作用
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