Sakakibara N, Gasa S, Kamio K, Makita A, Nonomura K, Togashi M, Koyanagi T, Hatae Y, Takeda K
Department of Urology, Hokkaido University School of Medicine, Sapporo, Japan.
Cancer Lett. 1991 May 24;57(3):187-92. doi: 10.1016/0304-3835(91)90155-b.
Glycolipid patterns were analysed chromatographically in Wilms' tumor and renal cell carcinoma tissues and compared with those of uninvolved tissue. Ganglioside GM3 was found to be increased in both cancer tissues, whereas sulfatides accumulated only in renal cell carcinoma, as reported earlier. Neolactotetraosylceramide was detected in both cancer tissues, but not in the uninvolved kidney tissues. In four cases of Wilms' tumors, only a low level of sulfotransferase towards galactosylceramide was found in one case, while no activity was detected in the three other cases. Present results show that the increased sulfatide(s) in the renal cell carcinoma and the deficiency of the sulfatides in Wilms' tumors appear to be biochemical characteristics of histologically different carcinomas.
采用色谱法分析了肾母细胞瘤和肾细胞癌组织中的糖脂模式，并与未受累组织的糖脂模式进行了比较。如先前报道，神经节苷脂GM3在两种癌组织中均有增加，而硫脂仅在肾细胞癌中积累。在两种癌组织中均检测到新乳糖四糖神经酰胺，但在未受累的肾组织中未检测到。在4例肾母细胞瘤中，仅1例发现对半乳糖基神经酰胺的硫酸转移酶水平较低，而其他3例未检测到活性。目前的结果表明，肾细胞癌中硫脂增加以及肾母细胞瘤中硫脂缺乏似乎是组织学上不同癌症的生化特征。
