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Metabolism of amino-acids: The synthesis of glutamine from glutamic acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues.

作者信息

Krebs H A

机构信息

The Biochemical Laboratory, Cambridge.

出版信息

Biochem J. 1935 Aug;29(8):1951-69. doi: 10.1042/bj0291951.

DOI:10.1042/bj0291951
PMID:16745865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1266709/
Abstract
摘要

相似文献

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Metabolism of amino-acids: The synthesis of glutamine from glutamic acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues.氨基酸的代谢：由谷氨酸和氨合成谷氨酰胺，以及动物组织中谷氨酰胺的酶促水解。
Biochem J. 1935 Aug;29(8):1951-69. doi: 10.1042/bj0291951.
2
EFFECTS OF DIELDRIN, PICROTOXIN AND TELODRIN ON THE METABOLISM OF AMMONIA IN BRAIN.狄氏剂、印防己毒素和异狄氏剂对脑内氨代谢的影响
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3
[Effect of succinic semialdehyde on nitrogen metabolism of animal brain tissue during hypoxia].[丁二酸半醛对缺氧时动物脑组织氮代谢的影响]
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4
[Effect of glutamic acid and caffeine on the content of glutamine, ammonia, glutamic and adenosinetriphosphoric acids in the greater hemispheres of the brain].[谷氨酸和咖啡因对大脑半球中谷氨酰胺、氨、谷氨酸和三磷酸腺苷含量的影响]
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Energy metabolism in brain cells: effects of elevated ammonia concentrations.脑细胞中的能量代谢：氨浓度升高的影响。
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6
Glutamic acid as a precursor to N-terminal pyroglutamic acid in mouse plasmacytoma protein (protein synthesis-initiation-immunoglobulins-pyrrolidone carboxylic acid).谷氨酸作为小鼠浆细胞瘤蛋白中N端焦谷氨酸的前体（蛋白质合成起始-免疫球蛋白-吡咯烷酮羧酸）。
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Characterization of amino acid metabolism by cultured rat kidney cells: study with 15N.培养的大鼠肾细胞氨基酸代谢的特征：用15N进行的研究
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Effects of prolonged exercise on brain ammonia and amino acids.长时间运动对脑氨和氨基酸的影响。
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[THE AMMONIA-GLUTAMIC ACID-GLUTAMINE SYSTEM IN THE RAT BRAIN IN THE DEVELOPMENT OF EXTRACEREBRAL MALIGNANT NEOPLASMS].[大鼠脑内氨-谷氨酸-谷氨酰胺系统在脑外恶性肿瘤发生发展中的作用]
Ukr Biokhim Zh. 1963;35:709-12.
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Ammoniagenesis in renal cell culture. Lack of extracellular ammoniagenesis at the apical surface of LLC-PK1 epithelia.肾细胞培养中的氨生成。LLC-PK1上皮细胞顶端表面缺乏细胞外氨生成。
Ren Physiol Biochem. 1993 Jul-Aug;16(4):203-11.

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Glutamine Supplementation: A Possible Strategy to Help Mitigate Health Risks of Heat-Related Illness.补充谷氨酰胺：一种有助于减轻热相关疾病健康风险的可能策略。
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Prostate Cancer's Silent Partners: Fibroblasts and Their Influence on Glutamine Metabolism Manipulation.前列腺癌的沉默伙伴：成纤维细胞及其对谷氨酰胺代谢操纵的影响。
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HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell Renal Cell Carcinoma.缺氧诱导因子2α（HIF2α）抑制线粒体中谷氨酰胺酶聚集，以维持肾透明细胞癌的生长。
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Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.脯氨酸代谢限速酶 P5CS 的抑制作用可促进谷氨酰胺限制的癌细胞增殖。
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Mitochondrial transplantation ameliorates doxorubicin-induced cardiac dysfunction via activating glutamine metabolism.线粒体移植通过激活谷氨酰胺代谢改善阿霉素诱导的心脏功能障碍。
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J Hematol Oncol. 2023 Jun 5;16(1):59. doi: 10.1186/s13045-023-01453-1.

本文引用的文献

1
Metabolism of normal and tumour tissue: Ammonia and urea formation.正常组织与肿瘤组织的代谢：氨和尿素的形成。
Biochem J. 1933;27(4):1123-33. doi: 10.1042/bj0271123.
2
The estimation of glutamine in the presence of asparagine.在天冬酰胺存在的情况下对谷氨酰胺的测定。
Biochem J. 1932;26(1):122-32. doi: 10.1042/bj0260122.
3
The Amide Nitrogen of Caseinogen.酪蛋白原的酰胺氮
Biochem J. 1924;18(3-4):679-92. doi: 10.1042/bj0180679.