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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Cooper D R, Davidson R J

Leather Industries Research Institute, Rhodes University, Grahamstown, South Africa.

Biochem J. 1965 Oct;97(1):139-47. doi: 10.1042/bj0970139.

The effect of ultraviolet irradiation on acid-soluble and neutral-salt-soluble calf-skin collagen was studied by chromatography, gel filtration, amino acid analysis and sedimentation of the sub-units, and the reaction kinetics of degradation were obtained from viscosity and optical rotation measurements. 2. It was demonstrated that, whereas the structure of neutral-salt-soluble calf-skin collagen may be represented by the formula (alpha(1))(2)alpha(2), the acid-soluble extract has the formula alpha(1).(alpha(2))(2). The acid-soluble collagen is also unusual in containing a large amount of a component that could be beta(22). 3. Ultraviolet irradiation causes the progressive degradation of the collagen molecule into smaller molecular fragments that subsequently lose their helical nature. The rate constants show that the denaturation of soluble collagens by ultraviolet irradiation is much slower, under the conditions used, than denaturation by heat or enzymes.

通过色谱法、凝胶过滤法、氨基酸分析以及亚基沉降法研究了紫外线照射对酸溶性和中性盐溶性小牛皮胶原蛋白的影响，并通过粘度和旋光测量获得了降解反应动力学。2. 结果表明，中性盐溶性小牛皮胶原蛋白的结构可用公式(α(1))(2)α(2)表示，而酸溶性提取物的公式为α(1)·(α(2))(2)。酸溶性胶原蛋白还含有大量可能是β(22)的成分，这也很不寻常。3. 紫外线照射会使胶原蛋白分子逐渐降解为较小的分子片段，这些片段随后会失去其螺旋结构。速率常数表明，在所使用的条件下，紫外线照射导致可溶性胶原蛋白变性的速度比热或酶导致的变性要慢得多。

Cooper D R, Davidson R J

Leather Industries Research Institute, Rhodes University, Grahamstown, South Africa.

Biochem J. 1965 Oct;97(1):139-47. doi: 10.1042/bj0970139.

The effect of ultraviolet irradiation on acid-soluble and neutral-salt-soluble calf-skin collagen was studied by chromatography, gel filtration, amino acid analysis and sedimentation of the sub-units, and the reaction kinetics of degradation were obtained from viscosity and optical rotation measurements. 2. It was demonstrated that, whereas the structure of neutral-salt-soluble calf-skin collagen may be represented by the formula (alpha(1))(2)alpha(2), the acid-soluble extract has the formula alpha(1).(alpha(2))(2). The acid-soluble collagen is also unusual in containing a large amount of a component that could be beta(22). 3. Ultraviolet irradiation causes the progressive degradation of the collagen molecule into smaller molecular fragments that subsequently lose their helical nature. The rate constants show that the denaturation of soluble collagens by ultraviolet irradiation is much slower, under the conditions used, than denaturation by heat or enzymes.

通过色谱法、凝胶过滤法、氨基酸分析以及亚基沉降法研究了紫外线照射对酸溶性和中性盐溶性小牛皮胶原蛋白的影响，并通过粘度和旋光测量获得了降解反应动力学。2. 结果表明，中性盐溶性小牛皮胶原蛋白的结构可用公式(α(1))(2)α(2)表示，而酸溶性提取物的公式为α(1)·(α(2))(2)。酸溶性胶原蛋白还含有大量可能是β(22)的成分，这也很不寻常。3. 紫外线照射会使胶原蛋白分子逐渐降解为较小的分子片段，这些片段随后会失去其螺旋结构。速率常数表明，在所使用的条件下，紫外线照射导致可溶性胶原蛋白变性的速度比热或酶导致的变性要慢得多。