水杨酸盐对线粒体片段氧化磷酸化及呼吸作用的影响。
Effect of salicylate on oxidative phosphorylation and respiration of mitochondrial fragments.
作者信息
Miyahara J T, Karler R
机构信息
Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah, U.S.A.
出版信息
Biochem J. 1965 Oct;97(1):194-8. doi: 10.1042/bj0970194.
Abstract
- The effects of salicylate on oxidative phosphorylation and respiration were investigated in liver and brain mitochondria, and in sonically prepared mitochondrial fragments. 2. Salicylate was shown to uncouple oxidative phosphorylation in mitochondrial fragments, as well as in intact mitochondria. The effects of salicylate on mitochondria and oxidative phosphorylation resemble those produced by dinitrophenol. 3. The quantitative effects of salicylate on respiration in vitro were shown to be complex. The final effect may be the resultant of an interaction of a multiplicity of factors, such as the tissue, the substrate, mitochondrial and extramitochondrial influences, and the direct effect on the respiratory chain itself.
摘要
- 研究了水杨酸盐对肝脏和脑线粒体以及超声处理的线粒体片段中氧化磷酸化和呼吸作用的影响。2. 结果表明，水杨酸盐可使线粒体片段以及完整线粒体中的氧化磷酸化解偶联。水杨酸盐对线粒体和氧化磷酸化的影响类似于二硝基苯酚所产生的影响。3. 水杨酸盐对体外呼吸作用的定量影响显示是复杂的。最终效应可能是多种因素相互作用的结果，这些因素包括组织、底物、线粒体和线粒体外的影响以及对呼吸链本身的直接影响。
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