Friesen Marjorie S, Purssell Roy A, Gair Robert D
British Columbia Drug and Poison Information Centre, Vancouver, Canada.
Clin Toxicol (Phila). 2006;44(3):307-14. doi: 10.1080/15563650600637077.
Aluminum toxicity has been reported in renal failure patients exposed to aluminum-contaminated dialysate and oral phosphate binders. We report a case of significant aluminum toxicity in a non-hemodialysis patient.
A 43-year-old male IV drug user presented to the hospital with a seizure disorder of recent onset, progressive cognitive decline, ataxia, and dysarthria. The serum aluminum concentration was 180 micrograms/L (6.65 micromol/L). For 3 to 4 years prior, the patient had injected 'cooked' oral methadone. The methadone solution was heated in an aluminum pot to reduce the volume and then injected intravenously (IV). He was treated with IV deferoxamine over 9 months until he failed to return. Serum aluminum level after 9 months of treatment was 64.5 microgram/L (2.39 micromol/L). Neurological symptoms were partially improved.
Chronic IV injection of oral methadone solution heated in an aluminum-based cooking utensil may result in significant aluminum toxicity.
据报道，接触受铝污染的透析液和口服磷酸盐结合剂的肾衰竭患者会出现铝中毒。我们报告一例非血液透析患者发生严重铝中毒的病例。
一名43岁的男性静脉吸毒者因近期发作的癫痫、进行性认知衰退、共济失调和构音障碍入院。血清铝浓度为180微克/升（6.65微摩尔/升）。在之前的3至4年里，该患者一直注射“煮过的”口服美沙酮。美沙酮溶液在铝锅中加热以减少体积，然后静脉注射。他接受了9个月的静脉去铁胺治疗，直到不再前来复诊。治疗9个月后的血清铝水平为64.5微克/升（2.39微摩尔/升）。神经症状有部分改善。
长期静脉注射在铝制炊具中加热的口服美沙酮溶液可能导致严重的铝中毒。
