Nes R B, Røysamb E, Tambs K, Harris J R, Reichborn-Kjennerud T
Division of Mental Health, The Norwegian Institute of Public Health, Oslo, Norway.
Psychol Med. 2006 Jul;36(7):1033-42. doi: 10.1017/S0033291706007409.
Previous cross-sectional studies have found substantial genetic influences on individual variation in subjective well-being (SWB), and evidence for sex-specific genetic effects has been reported. However, the genetic and environmental influences on stability and change in SWB over time are largely unexplored.
Questionnaire data on SWB from a population-based sample of Norwegian twins born 1967 to 1979, initially surveyed in 1992 (T1) and re-surveyed in 1998 (T2), were analysed using structural equation modelling to explore the relative effects of genetic and environmental influences on phenotypic stability and change.
The phenotypic cross-time correlations for SWB were 0.51 and 0.49 for males and females respectively. The best-fitting longitudinal model specified only additive genetic and individual environmental effects with qualitative and quantitative sex-specific genetic influences. For both males and females, the additive genetic factors influencing SWB were largely stable, although some time-specific genetic contributions were indicated. Cross-time correlations for genetic effects were 0.85 and 0.78 for males and females respectively. The individual environmental influences were primarily time-specific. Additive genetic effects explained approximately 80% of the phenotypic cross-time correlation. For females, the magnitude of the additive genetic effects decreased significantly from T1 to T2, whereas for males, the estimates generally remained unchanged.
For both males and females, long-term stability of SWB was mainly attributable to stable additive genetic factors, whereas susceptibility to change was mostly related to individual environmental factors. However, both stable environmental contributions and emerging genetic influences were indicated.
以往的横断面研究发现,主观幸福感(SWB)的个体差异受基因影响很大,并且已有报道表明存在性别特异性基因效应的证据。然而,基因和环境对SWB随时间的稳定性和变化的影响在很大程度上尚未得到探索。
利用结构方程模型分析了1967年至1979年出生的挪威双胞胎群体样本中关于SWB的问卷数据,这些双胞胎最初于1992年接受调查(T1),并于1998年再次接受调查(T2),以探讨基因和环境影响对表型稳定性和变化的相对作用。
男性和女性SWB的表型跨时间相关性分别为0.51和0.49。拟合度最佳的纵向模型仅指定了加性基因效应和个体环境效应,以及定性和定量的性别特异性基因影响。对于男性和女性,加性基因因素在很大程度上是稳定的,尽管显示出一些特定时间的基因贡献。男性和女性基因效应的跨时间相关性分别为0.85和0.78。个体环境影响主要是特定时间的。加性基因效应解释了约80%的表型跨时间相关性。对于女性,从T1到T2,加性基因效应的大小显著下降,而对于男性,估计值总体保持不变。
对于男性和女性而言,SWB的长期稳定性主要归因于稳定的加性基因因素,而变化的易感性大多与个体环境因素有关。然而也表明存在稳定的环境贡献和新出现 的基因影响。