Paoloni-Giacobino Ariane
Department of Molecular Genetics and Biochemistry, University of Pittsburgh Medical School, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
Expert Rev Mol Med. 2006 Jun 5;8(12):1-14. doi: 10.1017/S1462399406010933.
Assisted reproductive techniques (ARTs) have been widely used over the past two decades to help infertile couples conceive. Recent studies on the ART-conceived population have raised concern about the possible risks of these techniques, in particular with regard to increased incidence of growth and developmental disorders. Some of these effects might be linked to genomic imprinting defects, although current evidence does not allow definite conclusions to be drawn. This review summarises studies that have examined effects of gamete and embryo manipulations on imprinted genes, and discusses the evidence for and against effects of ARTs on offspring health, and in particular imprinting-related conditions.
在过去二十年中，辅助生殖技术（ARTs）已被广泛用于帮助不孕夫妇受孕。最近对通过辅助生殖技术受孕人群的研究引发了对这些技术可能存在风险的担忧，尤其是关于生长和发育障碍发病率增加的问题。其中一些影响可能与基因组印记缺陷有关，尽管目前的证据尚无法得出明确结论。这篇综述总结了研究配子和胚胎操作对印记基因影响的研究，并讨论了支持和反对辅助生殖技术对后代健康有影响的证据，特别是与印记相关的病症。
