Lidegaard Øjvind, Pinborg Anja, Andersen Anders Nyboe
Gynaecologic Clinic Juliane, Marie Centre, Copenhagen, Denmark.
Curr Opin Obstet Gynecol. 2006 Jun;18(3):293-6. doi: 10.1097/01.gco.0000193006.42910.ee.
To assess the evidence of an increased risk of imprinting diseases in children born after use of assisted reproductive technologies.
Imprinting disorders occur when the epigenetic programming during gametogenesis is disturbed, or when this programming is not sufficiently sustained during the process of fertilization and early embryonic development. Ten case or case-reference reports have been published suggesting that compared with reference populations, a higher proportion of children with imprinting diseases were conceived by assisted reproductive technologies. These reports are inconsistent in linking the risk to a specific assisted reproductive technology, and a cytogenetic examination assessing the exact genetic imprinting mechanism was not always provided. Two national systematic follow-up studies on 6052 Danish and 16,280 Swedish in-vitro fertilization children found none and two children with imprinting diseases, respectively. These figures correspond approximately to the expected number of children with imprinting disease from the general population.
The evidence of an increased risk of imprinting diseases in children conceived by assisted reproductive technologies is limited. The published case reports, however, call for a systematic multinational long-term follow-up of children born after assisted reproductive technologies.
评估使用辅助生殖技术后出生的儿童患印记疾病风险增加的证据。
当配子发生过程中的表观遗传编程受到干扰，或者在受精和早期胚胎发育过程中这种编程没有得到充分维持时，就会发生印记障碍。已发表了10篇病例或病例对照报告，表明与参考人群相比，通过辅助生殖技术受孕的儿童中患印记疾病的比例更高。这些报告在将风险与特定辅助生殖技术联系起来方面并不一致，而且并不总是提供评估确切遗传印记机制的细胞遗传学检查。两项针对6052名丹麦体外受精儿童和16280名瑞典体外受精儿童的全国性系统随访研究分别发现0例和2例患印记疾病的儿童。这些数字大致相当于普通人群中患印记疾病儿童的预期数量。
辅助生殖技术受孕儿童患印记疾病风险增加的证据有限。然而，已发表的病例报告呼吁对辅助生殖技术后出生的儿童进行系统的跨国长期随访。
