Y Jyothi, Kamath Jagadish V, Asad Mohammed
Krupanidhi College of Pharmacy, 5, Sarjapur Road, Koramangala, Bangalore-560 034, India.
Pak J Pharm Sci. 2006 Apr;19(2):129-33.
The hexane extract of oleo-gum-resin of Boswellia serrata (BSHE) was evaluated for its effect on liver injury induced by carbon tetrachloride, paracetamol or thioacetamide. The BSHE was given in two different doses (87.5 mg/kg p.o. and 175 mg/kg p.o.). Silymarin, a known hepatoprotective agent was used as standard. The lower dose of BSHE (87.5 mg/kg p.o.) significantly reduced the elevated levels of serum marker enzymes and prevented the increase in liver weight in all three models of liver injury, while the higher dose showed mild hepatoprotective activity. The hepatoprotective effect of lower dose of BSHE was supported by changes in histopathology. It was concluded that hexane extract of oleo-gum-resin of Boswellia serrata plant in lower doses possess hepatoprotective activity.
对锯叶乳香（Boswellia serrata）油胶树脂的己烷提取物进行了评估，以研究其对四氯化碳、扑热息痛或硫代乙酰胺所致肝损伤的影响。己烷提取物以两种不同剂量（87.5毫克/千克口服和175毫克/千克口服）给药。水飞蓟素，一种已知的肝保护剂用作标准对照。较低剂量的己烷提取物（87.5毫克/千克口服）在所有三种肝损伤模型中均显著降低了血清标志物酶的升高水平，并防止了肝脏重量增加，而较高剂量则显示出轻度的肝保护活性。组织病理学变化支持了较低剂量己烷提取物的肝保护作用。得出的结论是，较低剂量的锯叶乳香植物油胶树脂己烷提取物具有肝保护活性。
