Roy Chanchal K, Kamath Jagadish V, Asad Mohammed
Krupanidhi College of Pharmacy, Koramangala, Bangalore, India.
Indian J Exp Biol. 2006 Apr;44(4):305-11.
The study was designed to evaluate the hepatoprotective activity of P. guajava in acute experimental liver injury induced by carbon tetrachloride, paracetamol or thioacetamide and chronic liver damage induced by carbon tetrachloride. The effects observed were compared with a known hepatoprotective agent, silymarin. In the acute liver damage induced by different hepatotoxins, P. guajava leaf extracts (250 and 500mg/kg, po) significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. The higher dose of the extract (500 mg/kg, po) prevented the increase in liver weight when compared to hepatoxin treated control, while the lower dose was ineffective except in the paracetamol induced liver damage. In the chronic liver injury induced by carbon tetrachloride, the higher dose (500 mg/kg, po) of P. guajava leaf extract was found to be more effective than the lower dose (250 mg/kg, po). Histological examination of the liver tissues supported the hepatoprotection. It is concluded that the aqueous extract of leaves of guava plant possesses good hepatoprotective activity.
本研究旨在评估番石榴在四氯化碳、对乙酰氨基酚或硫代乙酰胺诱导的急性实验性肝损伤以及四氯化碳诱导的慢性肝损伤中的肝脏保护活性。将观察到的效果与已知的肝脏保护剂水飞蓟宾进行比较。在不同肝毒素诱导的急性肝损伤中，番石榴叶提取物（250和500mg/kg，口服）显著降低了升高的血清天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶和胆红素水平。与肝毒素处理的对照组相比，较高剂量的提取物（500mg/kg，口服）可防止肝脏重量增加，而较低剂量除对乙酰氨基酚诱导的肝损伤外无效。在四氯化碳诱导的慢性肝损伤中，发现较高剂量（500mg/kg，口服）的番石榴叶提取物比较低剂量（250mg/kg，口服）更有效。肝脏组织的组织学检查支持了肝脏保护作用。得出的结论是，番石榴植物叶的水提取物具有良好的肝脏保护活性。
