Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Inflammopharmacology. 2019 Jun;27(3):549-559. doi: 10.1007/s10787-018-0519-4. Epub 2018 Aug 1.
The role of proinflammatory cytokines in adiposity is well established. The anti-inflammatory and antihyperglycemia effects of Boswellia serrata (B. Serrata) gum have been demonstrated by many investigators. The present study aimed to investigate the anti-obesity potential of B. serrata extract.
The effects of B. serrata extract on lipase activity and acute food intake were investigated. The present study aimed to investigate the anti-obesity potential of B. serrata extract. The effects on lipase activity and acute food intake were investigated. Body weight changes, biochemical and histopathological markers were demonstrated in rats fed a high-fat diet.
Boswellia serrata extract inhibited alterations in pancreatic lipase activity, but orlistat was more efficacious. B. serrata and ephidrene, but not orlistat, significantly suppressed cumulative food intake in mice. In obese rats, B. serrata or orlistat significantly decreased weight gain and weight of visceral white adipose tissue. B. serrata-treated animals exhibited a significant reduction in serum glucose, TC, TG, LDL-C, FFA, IL-1β, TNF-α, insulin and leptin levels of obese rat groups while HDL-C and adiponectin levels were significantly increased by orlistat or B. serrata extract. Histopathological examination of the liver revealed that B. serrata was more effective than orlistat in alleviating steatosis and adipocyte hypertrophy shown in obese control rats.
Boswellia serrata is as effective as orlistat in preventing obesity, hyperlipidemia, steatosis and insulin resistance. These actions may be mediated by suppression of food intake and decrease levels of TNF-α, IL-1β and leptin resistance along with increasing adiponectin.
促炎细胞因子在肥胖中的作用已得到充分证实。许多研究人员已经证明，乳香（B. Serrata）胶具有抗炎和降血糖作用。本研究旨在研究乳香提取物的抗肥胖潜力。
研究了乳香提取物对脂肪酶活性和急性食物摄入的影响。本研究旨在研究乳香提取物的抗肥胖潜力。研究了对脂肪酶活性和急性食物摄入的影响。在高脂肪饮食喂养的大鼠中证明了体重变化、生化和组织病理学标志物。
乳香提取物抑制了胰腺脂肪酶活性的改变，但奥利司他更有效。乳香和 Ephidrene，但不是奥利司他，显著抑制了小鼠的累积食物摄入量。在肥胖大鼠中，乳香或奥利司他显著降低了体重增加和内脏白色脂肪组织的重量。乳香处理的动物表现出显著降低肥胖大鼠组的血清葡萄糖、TC、TG、LDL-C、FFA、IL-1β、TNF-α、胰岛素和瘦素水平，而 HDL-C 和脂联素水平则显著升高由奥利司他或乳香提取物。肝脏的组织病理学检查表明，乳香在缓解肥胖对照大鼠中显示的脂肪肝和脂肪细胞肥大方面比奥利司他更有效。
乳香与奥利司他一样有效，可以预防肥胖、高血脂、脂肪肝和胰岛素抵抗。这些作用可能是通过抑制食物摄入和降低 TNF-α、IL-1β 和瘦素抵抗水平以及增加脂联素来介导的。
