Amin Amr, Hamza Alaaeldin A
Department of Biology, United Arab Emirates University, Al-Ain 17555, United Arab Emirates.
Asian J Androl. 2006 Sep;8(5):607-12. doi: 10.1111/j.1745-7262.2006.00179.x. Epub 2006 Jun 5.
To evaluate the protective effects of Hibiscus sabdariffa (Roselle) and Zingiber officinale (Ginger) against cisplatin-induced reproductive toxicity in rats and to study the mechanisms underlying these effects.
Ethanol extracts of H.sabdariffa or Z.officinale (1g/kg x day) were given p.o. to male albino rats for 26 days, which began 21 days before a single cisplatin i.p. injection (10 mg/kg body weight).
Extracts of H.sabdariffa and Z.officinale reduced the extent of cisplatin-induced sperm abnormality and enhanced sperm motility. Both extracts restored the control level of malondialdehyde (MDA) (lipid peroxidation marker) in the cisplatin-treated testis. The cisplatin injection induced decline in the levels of superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT) were significantly reversed to control levels in groups where cisplatin was preceded by the administration of either H.sabdariffa or Z.officinale.
Both H.sabdariffa and Z.officinale treatment increased the activities of testicular antioxidant enzymes and restored sperm motility of cisplatin-treated rats. The protective effects of tested plants are, therefore, suggested to be mediated by their potent antioxidant activities.
评估玫瑰茄和生姜对顺铂诱导的大鼠生殖毒性的保护作用，并研究其作用机制。
将玫瑰茄或生姜的乙醇提取物（1克/千克×天）经口给予雄性白化大鼠，持续26天，给药在单次腹腔注射顺铂（10毫克/千克体重）前21天开始。
玫瑰茄和生姜提取物降低了顺铂诱导的精子异常程度，增强了精子活力。两种提取物均使顺铂处理的睾丸中丙二醛（MDA，脂质过氧化标志物）的水平恢复到对照水平。顺铂注射导致的超氧化物歧化酶（SOD）、还原型谷胱甘肽（GSH）和过氧化氢酶（CAT）水平下降，在给予玫瑰茄或生姜预处理的组中显著逆转至对照水平。
玫瑰茄和生姜处理均增加了顺铂处理大鼠睾丸抗氧化酶的活性，并恢复了精子活力。因此，所测试植物的保护作用可能是由其强大的抗氧化活性介导的。
