Amin Amr, Hamza Alaaeldin A, Kambal Amr, Daoud Sayel
Biology Department, United Arab Emirates University, Al-Ain 17551, United Arab Emirates.
Asian J Androl. 2008 Mar;10(2):291-7. doi: 10.1111/j.1745-7262.2008.00379.x. Epub 2007 Dec 20.
To evaluate the protective effects of ginger (Gin) and roselle (Ros) against testicular damage and oxidative stress in a cisplatin (CIS)-induced rodent model. Their protective effects against CIS-induced apoptosis in testicular and epididymal sperms is also investigated.
Ethanol extracts of Gin or Ros (1 g/kg.day) were given orally to male albino rats for 26 days. This period began 21 days before a single CIS intraperitoneal injection (10 mg/kg body weight).
Gin or Ros given orally significantly restored reproductive function. Both tested extracts notably reduced the CIS-induced reproductive toxicity, as evidenced by restoring the testis normal morphology. In Gin and Ros, the attenuation of CIS-induced damage was associated with less apoptotic cell death both in the testicular tissue and in the sperms. CIS-induced alterations of testicular lipid peroxidation were markedly improved by these plant extracts.
The present results provide further insights into the mechanisms of protection against CIS-induced reproductive toxicity and confirm the essential anti-oxidant potential of both examined extracts.
在顺铂（CIS）诱导的啮齿动物模型中，评估生姜（Gin）和玫瑰茄（Ros）对睾丸损伤和氧化应激的保护作用。还研究了它们对CIS诱导的睾丸和附睾精子凋亡的保护作用。
将Gin或Ros的乙醇提取物（1克/千克·天）口服给予雄性白化大鼠，持续26天。这段时间在单次腹腔注射CIS（10毫克/千克体重）前21天开始。
口服Gin或Ros可显著恢复生殖功能。两种受试提取物均显著降低了CIS诱导的生殖毒性，恢复睾丸正常形态即可证明。在Gin和Ros组中，CIS诱导损伤的减轻与睾丸组织和精子中凋亡细胞死亡减少有关。这些植物提取物显著改善了CIS诱导的睾丸脂质过氧化改变。
目前的结果为预防CIS诱导的生殖毒性的机制提供了进一步见解，并证实了两种受试提取物的基本抗氧化潜力。
