Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
JBRA Assist Reprod. 2023 Mar 30;27(1):41-48. doi: 10.5935/1518-0557.20220017.
In this study we evaluated the influence of Alpinia officinarum rhizome extract (AO) on the alleviation of testicular damage induced by cisplatin in rats.
The study groups included the control group, AO-administered group, cisplatin-administered group, and three groups administered with cisplatin and AO (different concentrations of 100, 200, and 400 mg/kg). On the 14th day we removed the testes of the rats, and the testicular organ parameters were measured. Moreover, through the malondialdehyde concentration we assessed the oxidative stress and superoxide dismutase (SOD) activity of the testes and ran a histopathological analysis.
The results demonstrated that cisplatin-induced oxidative stress and severe testicular damage on the AO-administered group showed no harm compared with the control group. AO- treatment in cisplatin-received rats led to the reduction of oxidative stress, enhancement of SOD activity, and prevention of testicular damage. The lowest testis damage was attributed to the group which received 400 mg/kg of AO compared to 100 and 200 mg/kg.
Overall, the Cis+/AO+400 group had the best antioxidant effect. The findings could lead to changes in cancer care guidelines that incorporate phytochemicals, making cancer therapies safer.
本研究评估了高良姜根茎提取物（AO）对顺铂诱导的大鼠睾丸损伤缓解的影响。
研究组包括对照组、AO 给药组、顺铂给药组和三组给予顺铂和 AO（浓度分别为 100、200 和 400mg/kg）。第 14 天，我们取出大鼠的睾丸，测量睾丸器官参数。此外，通过丙二醛浓度评估睾丸的氧化应激和超氧化物歧化酶（SOD）活性，并进行组织病理学分析。
结果表明，与对照组相比，顺铂诱导的氧化应激和严重的睾丸损伤在 AO 给药组中没有造成伤害。顺铂接受大鼠的 AO 治疗导致氧化应激减少，SOD 活性增强，睾丸损伤得到预防。与 100 和 200mg/kg 相比，400mg/kg 的 AO 组睾丸损伤最小。
总体而言，Cis+/AO+400 组具有最佳的抗氧化效果。这些发现可能会导致癌症治疗指南的改变，纳入植物化学物质，使癌症治疗更安全。
