Faraj M, Messier L, Bastard J P, Tardif A, Godbout A, Prud'homme D, Rabasa-Lhoret R
Faculty of Medicine, Department of Nutrition, University of Montréal, 2405 Chemin Côte Ste-Catherine, Montréal, QC, H3T 1A8, Canada.
Diabetologia. 2006 Jul;49(7):1637-46. doi: 10.1007/s00125-006-0259-7. Epub 2006 May 3.
AIMS/HYPOTHESIS: Inflammation is implicated in the development of type 2 diabetes and CHD, but the trigger of inflammation is unclear. Although in vitro and animal studies support a role of elevated levels of atherosclerotic lipoproteins in the activation of inflammation, plasma cholesterol cannot predict inflammatory markers in humans. Moreover, the association between inflammatory markers and other traditional risk factors of diabetes and CHD is unclear. To increase our knowledge of in vivo regulation of inflammation, we examined the association between several traditional risk factors and inflammatory markers. We hypothesised that because apolipoprotein B (ApoB) reflects atherogenic particle number, it is the primary predictor of inflammatory status.
SUBJECTS, MATERIALS AND METHODS: We examined the association between several traditional risk factors and plasma high-sensitivity (hs) C-reactive protein (CRP), hsTNF-alpha, soluble TNF receptor 1, IL-6, orosomucoid, haptoglobin and alpha(1)-antitrypsin in 77 non-diabetic overweight and obese postmenopausal women.
The inflammatory markers correlated positively with total and abdominal adiposity, blood pressure, 2-h OGTT glucose, insulin resistance, triglyceride, total/HDL cholesterol, ApoB, ApoB:apolipoprotein A1 (ApoA1) ratio and Framingham CHD risk points. They correlated negatively with ApoA1, and total, LDL and HDL cholesterol. ApoB was an independent predictor of the interindividual variation in IL-6, hsCRP, orosomucoid, haptoglobin and alpha(1)-antitrypsin (R (2) range 8-40%); other risk factors were less predictive. Compared with BMI-matched control subjects, women with hyperapobetalipoproteinaemia (hyperapoB) had higher hsTNF-alpha, IL-6, hsCRP and orosomucoid (increase 17-104%).
CONCLUSIONS/INTERPRETATION: ApoB is the primary predictor of inflammatory markers in postmenopausal overweight and obese women. Given elevated levels of inflammatory markers in hyperapoB women, we hypothesise that hyperapoB women may have an increased risk of developing both CHD and diabetes.
目的/假设：炎症与2型糖尿病和冠心病的发生有关，但炎症的触发因素尚不清楚。尽管体外和动物研究支持动脉粥样硬化脂蛋白水平升高在炎症激活中的作用，但血浆胆固醇无法预测人类的炎症标志物。此外，炎症标志物与糖尿病和冠心病的其他传统危险因素之间的关联尚不清楚。为了增加我们对炎症体内调节的了解，我们研究了几种传统危险因素与炎症标志物之间的关联。我们假设，由于载脂蛋白B（ApoB）反映致动脉粥样硬化颗粒数量，它是炎症状态的主要预测指标。
受试者、材料和方法：我们研究了77名非糖尿病超重和肥胖绝经后妇女中几种传统危险因素与血浆高敏（hs）C反应蛋白（CRP）、hsTNF-α、可溶性TNF受体1、IL-6、血清类黏蛋白、触珠蛋白和α1抗胰蛋白酶之间的关联。
炎症标志物与总体脂和腹部肥胖、血压、2小时口服葡萄糖耐量试验血糖、胰岛素抵抗甘油三酯、总胆固醇/高密度脂蛋白胆固醇、ApoB、ApoB:载脂蛋白A1（ApoA1）比值和弗雷明汉姆冠心病风险评分呈正相关。它们与ApoA1以及总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇呈负相关。ApoB是个体间IL-6、hsCRP、血清类黏蛋白、触珠蛋白和α1抗胰蛋白酶变异的独立预测指标（R²范围为8%-40%）；其他危险因素的预测性较低。与体重指数匹配的对照受试者相比，高载脂蛋白B血症（hyperapoB）女性的hsTNF-α、IL-6、hsCRP和血清类黏蛋白水平更高（升高17%-104%）。
结论/解读：ApoB是绝经后超重和肥胖女性炎症标志物的主要预测指标。鉴于hyperapoB女性炎症标志物水平升高，我们假设hyperapoB女性患冠心病和糖尿病的风险可能增加。
