Linden Christian, Ahlborg Henrik G, Besjakov Jack, Gardsell Per, Karlsson Magnus K
Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Sweden.
J Bone Miner Res. 2006 Jun;21(6):829-35. doi: 10.1359/jbmr.060304.
This 2-year prospective controlled exercise intervention trial in 99 girls at Tanner stage 1, evaluating a school curriculum-based training program on a population-based level, showed that the annual gain in BMC, aBMD, and bone size was greater in the intervention group than in the controls.
Most exercise intervention studies in children, evaluating the accrual of BMD, include volunteers and use specifically designed osteogenic exercise programs. The aim of this study was to evaluate a 2-year general school-based exercise intervention program in a population-based cohort of girls at Tanner stage 1.
Forty-nine girls 7-9 years of age in grades 1 and 2 in one school were included in a school curriculum-based exercise intervention program of general physical activity for 40 minutes per school day (200 minutes/week). Fifty healthy age-matched girls in three neighboring schools, assigned to the general Swedish school curriculum of physical activity (60 minutes/week), served as controls. All girls were premenarchal, remaining in Tanner stage 1 during the study. BMC (g) and areal BMD (aBMD; g/cm2) were measured with DXA of the total body (TB), the lumbar spine (L2-L4 vertebrae), the third lumbar vertebra (L3), the femoral neck (FN), and the leg. Volumetric BMD (vBMD; g/cm3) and bone size were calculated at L3 and FN. Total lean body mass and total fat mass were estimated from the total body scan. Height and weight were also registered. Baseline measurements were performed before the intervention was initiated. Follow-up was done after 2 years.
No differences between the groups were found at baseline in age, anthropometrics, or bone parameters. The annual gain in BMC was greater in the intervention group than in the controls: L2-L4, mean 3.8 percentage points (p = 0.007); L3 vertebra, mean 7.2 percentage points (p < 0.001); legs, mean 3.0 percentage points (p = 0.07). The intervention group had a greater annual gain in aBMD: total body, mean 0.6 percentage points (p = 0.006), L2-L4, mean 1.2 percentage points (p = 0.02), L3 vertebra, mean 1.6 percentage points (p = 0.006); legs, mean 1.2 percentage points (p = 0.007). There was also a greater mean annual gain in bone size in the L3 vertebra (mean 1.8 percentage points; p < 0.001) and in the FN (mean 0.3 percentage points; p = 0.02).
A general school-based exercise program for 2 years for 7- to 9-year-old girls (baseline) enhances the accrual of BMC and BMD and increases bone size.
这项针对99名处于坦纳1期的女孩进行的为期2年的前瞻性对照运动干预试验，在人群层面评估了一项基于学校课程的培训计划，结果显示，干预组的骨矿物质含量（BMC）、骨密度（aBMD）和骨大小的年度增长幅度大于对照组。
大多数评估儿童骨密度增加情况的运动干预研究纳入的是志愿者，并使用专门设计的成骨运动计划。本研究的目的是在一个基于人群的坦纳1期女孩队列中评估一项为期2年的基于学校的常规运动干预计划。
一所学校1年级和2年级的49名7至9岁女孩被纳入一项基于学校课程的常规体育活动运动干预计划，每天进行40分钟的体育活动（每周200分钟）。另外三所相邻学校的50名年龄匹配的健康女孩，她们遵循瑞典学校常规体育活动课程（每周60分钟），作为对照组。所有女孩均为月经初潮前，在研究期间仍处于坦纳1期。通过双能X线吸收法（DXA）测量全身（TB）、腰椎（L2 - L4椎体）、第三腰椎（L3）、股骨颈（FN）和腿部的BMC（克）和面积骨密度（aBMD；克/平方厘米）。计算L3和FN处的体积骨密度（vBMD；克/立方厘米）和骨大小。通过全身扫描估算总体瘦体重和总脂肪量。还记录了身高和体重。在干预开始前进行基线测量。2年后进行随访。
两组在年龄、人体测量学指标或骨参数的基线水平上未发现差异。干预组BMC的年度增长幅度大于对照组：L2 - L4，平均3.8个百分点（p = 0.007）；L3椎体，平均7.2个百分点（p < 0.001）；腿部，平均3.0个百分点（p = 0.07）。干预组aBMD的年度增长幅度更大：全身，平均0.6个百分点（p = 0.006），L2 - L4，平均1.2个百分点（p = 0.02），L3椎体，平均1.6个百分点（p = 0.006）；腿部，平均1.2个百分点（p = 0.007）。L3椎体（平均1.8个百分点；p < 0.001）和FN（平均0.3个百分点；p = 0.02）的骨大小平均年度增长幅度也更大。
一项针对7至9岁女孩（基线）为期2年的基于学校的常规运动计划可促进BMC和BMD的增加，并增大骨大小。
