Cavalieri Ralph L, Cohen Wayne R
Department of Obstetrics and Gynecology, Jamaica Hospital Medical Center and the Weill-Cornell Medical College, New York, NY, USA.
J Matern Fetal Neonatal Med. 2006 May;19(5):265-9. doi: 10.1080/14767050600676075.
Antenatal corticosteroid therapy to enhance fetal lung maturation in pregnancies at risk for preterm delivery is used commonly, based on the assumption that its established benefits outweigh associated risks. Corticosteroid treatment does confer some risks, particularly with respect to restricted brain growth and disordered neuronal development. These alterations have the potential for long-term effects on health. They deserve further study, and should not be undervalued. Corticosteroid therapy should be applied selectively in those situations in which the risk of preterm birth is very high and the likelihood of severe respiratory distress syndrome substantial.
基于已确定的益处大于相关风险这一假设，产前使用皮质类固醇疗法来促进有早产风险的妊娠中胎儿肺成熟的情况很常见。皮质类固醇治疗确实存在一些风险，尤其是在脑生长受限和神经元发育紊乱方面。这些改变有可能对健康产生长期影响。它们值得进一步研究，不应被低估。皮质类固醇疗法应选择性地应用于早产风险非常高且严重呼吸窘迫综合征可能性很大的情况。
