Fu Guang-Miao, Qin Hai-Lin, Yu Shi-Shan, Yu Bo-Yang
College of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, China.
J Asian Nat Prod Res. 2006 Jan-Mar;8(1-2):29-34. doi: 10.1080/10286020500480308.
Yuexiandajisu D, a novel 18-nor-rosane-type dimeric diterpenoid, was isolated from the roots of Euphorbia ebracteolata Hayata. Its structure was elucidated as 6,3':7,2'-diepoxy-di-2,3-dihydroxy-18-nor-ros-1(10),2,4,15-tetraene by spectroscopic techniques (HSQC, HMBC, DQF-COSY, TOCSY, NOESY) and chemical methods. Yuexiandajisu D showed moderate cytotoxic activity against cancer cell lines on HCT-8 and Bel-7402, with IC50 values of 2.66 and 3.76 microM, respectively.
月腺大戟素D是一种新型的18-降-蔷薇烷型二聚二萜类化合物，从月腺大戟的根中分离得到。通过光谱技术（HSQC、HMBC、DQF-COSY、TOCSY、NOESY）和化学方法确定其结构为6,3':7,2'-二环氧-二-2,3-二羟基-18-降-蔷薇-1(10),2,4,15-四烯。月腺大戟素D对HCT-8和Bel-7402癌细胞系显示出中等细胞毒活性，IC50值分别为2.66和3.76微摩尔。
