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从大戟属植物中分离得到的两种新型细胞毒二苯乙酮衍生物。

Two new cytotoxic acetophenone derivatives from Euphorbia ebracteolata Hayata.

机构信息

Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, PR China.

出版信息

Fitoterapia. 2010 Jul;81(5):385-8. doi: 10.1016/j.fitote.2009.11.007. Epub 2009 Dec 1.

Abstract

Two new acetophenone derivatives were isolated from the roots of Euphorbia ebracteolata Hayata, their structures were elucidated as 2,4-dihydroxy-6-methoxyl-methylene-3-methyl-acetophenone (1) and 2-dihydroxy-6-methoxyl-methylene-3-methyl-acetophenone-4-O-beta-D-glucopyranoside (2) on the basis of chemical and spectroscopic methods including (1)D- and (2)D-NMR techniques, and their cytotoxic activities were investigated by using the MTT method.

摘要

从大飞扬草 Euphorbia ebracteolata Hayata 的根部分离得到两个新的苯乙酮衍生物,根据化学和光谱方法,包括(1)D 和(2)D-NMR 技术,确定它们的结构为 2,4-二羟基-6-甲氧基亚甲基-3-甲基苯乙酮(1)和 2-羟基-6-甲氧基亚甲基-3-甲基-4-O-β-D-吡喃葡萄糖基苯乙酮(2)。并通过 MTT 法研究了它们的细胞毒性活性。

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