用超临界二氧化碳从当归中提取阿魏酸。

Extraction of ferulic acid from Angelica sinensis with supercritical CO2.

作者信息

Sun Yongyue, Li Shufen, Song Huiting, Tian Songjiang

机构信息

Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China.

出版信息

Nat Prod Res. 2006 Jul 20;20(9):835-41. doi: 10.1080/14786410500462579.

DOI:10.1080/14786410500462579

PMID:16753921

Abstract

Extraction of pharmacologically active ingredient of ferulic acid from the root of Angelica sinensis with supercritical CO2 was investigated. The experimental results show that the extract yields were 0.87-4.06% at temperatures from 45 to 65 degrees Celsius and pressures from 30 to 50 MPa, and the maximum content of ferulic aicd in the extracts was about 0.35-0.37%, which is lower than that of 0.61-0.85% by conventional percolation methods. Ethanol was used as co-solvent in different ratios to raw materials in order to increase the content of ferulic acid in the extracts. The experimental results show that both the extract yields and the content of ferulic acid in the extracts increase greatly compared with pure CO2 extraction. When the ratio of ethanol to the raw material was 1.6, the content of ferulic acid in the extracts was 0.91-1.27%, indicating that supercritical fluid extraction (SFE) with CO2 in the presence of suitable co-solvent is superior to percolation in extracting polar ferulic acid from Angelica sinensis.

摘要

研究了用超临界二氧化碳从当归根中提取阿魏酸这种药理活性成分。实验结果表明，在45至65摄氏度的温度和30至50兆帕的压力下，提取物得率为0.87 - 4.06%，提取物中阿魏酸的最大含量约为0.35 - 0.37%，低于传统渗漉法的0.61 - 0.85%。使用乙醇作为共溶剂，与原料按不同比例混合，以提高提取物中阿魏酸的含量。实验结果表明，与纯二氧化碳萃取相比，提取物得率和提取物中阿魏酸的含量均大幅增加。当乙醇与原料的比例为1.6时，提取物中阿魏酸的含量为0.91 - 1.27%，表明在合适的共溶剂存在下用二氧化碳进行超临界流体萃取（SFE）在从当归中提取极性阿魏酸方面优于渗漉法。