Minim Invasive Ther Allied Technol. 2002 May;11(3):107-16. doi: 10.1080/136457002320174177.
Despite well-established bone-grafting techniques, large bone defects still represent a challenge for orthopaedic and reconstructive surgeons. Efforts have therefore been made to develop osteoconductive, osteoinductive and osteogenic bone-replacement systems. According to its original definition, tissue engineering is an 'interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function'. It is based on the understanding of tissue formation and regeneration, and aims to grow new functional tissues rather than to build new spare parts. This review focuses on the principles of tissue engineering applied to the creation of bioartificial bone tissue. Important aspects, such as osteogenic cells, matrix materials, inter- and intra-cellular communication, growth factors, gene therapy and current concepts of bone tissue engineering are reviewed. First clinical applications are discussed. An outlook provides insight into the possible future perspectives of bone tissue engineering.
尽管骨移植技术已成熟，但大的骨缺损对骨科和重建外科医生来说仍是一项挑战。因此，人们一直在努力开发具有骨传导性、骨诱导性和成骨性的骨替代系统。根据其最初的定义，组织工程是一个“跨学科领域，它将工程学原理和生命科学原理应用于生物替代品的开发，以恢复、维持或改善组织功能”。它基于对组织形成和再生的理解，旨在培育新的功能组织，而不是制造新的备用部件。本综述重点关注应用于创建生物人工骨组织的组织工程原理。对成骨细胞、基质材料、细胞间和细胞内通讯、生长因子、基因治疗以及骨组织工程的当前概念等重要方面进行了综述。讨论了首次临床应用。展望部分深入探讨了骨组织工程可能的未来前景。
