Jani B, Rajkumar C
Section of Care of the Elderly, Imperial College, London, UK.
Postgrad Med J. 2006 Jun;82(968):357-62. doi: 10.1136/pgmj.2005.036053.
There is an age related decline in various physiological processes. Vascular ageing is associated with changes in the mechanical and the structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance. Arterial compliance can be measured by different parameters like pulse wave velocity, augmentation index, and systemic arterial compliance. There is evidence that arterial compliance is reduced in disease states such as hypertension, diabetes, and end stage renal failure. Changes in arterial compliance can be present before the clinical manifestation of cardiovascular disease. Pharmacological and non-pharmacological measures have been shown to improve arterial compliance. Arterial compliance may constitute an early cardiovascular risk marker and may be useful in assessing the effects of drugs on the cardiovascular system. Pharmacogenetics and genetics of arterial compliance in the future will improve our knowledge and understanding about vascular ageing.
各种生理过程会随着年龄增长而衰退。血管老化与血管壁的力学和结构特性变化有关，这会导致动脉弹性丧失和动脉顺应性降低。动脉顺应性可以通过不同参数来测量，如脉搏波速度、增强指数和全身动脉顺应性。有证据表明，在高血压、糖尿病和终末期肾衰竭等疾病状态下，动脉顺应性会降低。在心血管疾病临床表现出现之前，动脉顺应性可能就已经发生变化。药理学和非药理学措施已被证明可改善动脉顺应性。动脉顺应性可能构成早期心血管风险标志物，并且可能有助于评估药物对心血管系统的影响。未来，动脉顺应性的药物遗传学和遗传学将增进我们对血管老化的认识和理解。
