Belleville Sylvie, Rouleau Nancie, Van der Linden Martial
Research center of the Institut Universitaire de Gériatrie de Montréal and Department of Psychology, University of Montreal, Montreal, Que., Canada.
Brain Cogn. 2006 Nov;62(2):113-9. doi: 10.1016/j.bandc.2006.04.006. Epub 2006 Jun 6.
This study measures the effect of Alzheimer's disease (AD) and normal aging on the inhibition of prepotent responses. AD patients, normal aged controls, and young subjects were tested with the Hayling task, which measures the ability to inhibit a semantically constrained response, and with the Stroop procedure. AD patients showed a severe deficit in both error rates and response time on the Hayling task. Inhibition was also impaired on the Stroop procedure, both when using raw performance and when using an inhibition score that controlled for reading and naming speed. Normal aged participants showed modest impairment relative to young controls on both tests. Examination of individual performance in AD patients indicated that the impairment was found in most patients on the Hayling test but in only a subgroup of patients on the Stroop test.
本研究测量了阿尔茨海默病（AD）和正常衰老对优势反应抑制的影响。对AD患者、正常老年对照组和年轻受试者进行了海林任务测试，该任务测量抑制语义受限反应的能力，并采用了斯特鲁普程序。AD患者在海林任务的错误率和反应时间上均表现出严重缺陷。在斯特鲁普程序中，无论是使用原始表现还是使用控制阅读和命名速度的抑制分数，抑制能力也都受损。正常老年参与者在两项测试中相对于年轻对照组表现出适度的损伤。对AD患者个体表现的检查表明，大多数患者在海林测试中存在损伤，但在斯特鲁普测试中只有部分患者存在损伤。
