Etimesgut Asker Hastanesi, Department of Psychiatry, Ankara, Turkey.
Erenkoy Training and Research Hospital for Psychiatric and Neurological Disorders, Department of Psychiatry, İstanbul, Turkey.
Brain Res Bull. 2014 May;104:82-7. doi: 10.1016/j.brainresbull.2014.04.005. Epub 2014 Apr 18.
This study aimed to investigate the effects of electroconvulsive treatment on serum BDNF and NGF levels in patients with treatment-resistant major depression.
Thirty patients with treatment-resistant major depression and 30 healthy controls were included in the study. The patients' serum BDNF and NGF levels were measured three times; before treatment (T0), when the clinical response occurred (T1) and at the end of treatment (T2).
The reduction detected in the HAM-D scores with ECT during the T0-T1, T1-T2 and T0-T2 periods was found to be statistically significant. In the patient group, increase in the mean BDNF levels after ECT treatment was found to be statistically significant (p<0.05). Significant increases in serum BDNF levels with ECT were lower than in the control group, and the serum NGF levels did not increase significantly. There was no relationship between the severity of the depression and serum BDNF and NGF levels (p>0.05).
This study evaluated the role of neurotrophic factors in the etiopathogenesis of major depression. Future studies should investigate the relationship between neurotrophic factors with neuroendocrine and genetic processes to elucidate the psychobiology and treatment of mental disorders.
本研究旨在探讨电抽搐治疗对治疗抵抗性重度抑郁症患者血清脑源性神经营养因子（BDNF）和神经生长因子（NGF）水平的影响。
研究纳入了 30 例治疗抵抗性重度抑郁症患者和 30 例健康对照者。患者的血清 BDNF 和 NGF 水平在治疗前（T0）、临床反应发生时（T1）和治疗结束时（T2）进行了 3 次测量。
ECT 在 T0-T1、T1-T2 和 T0-T2 期间的 HAM-D 评分降低被发现具有统计学意义。在患者组中，ECT 治疗后 BDNF 水平的升高具有统计学意义（p<0.05）。ECT 引起的血清 BDNF 水平升高显著低于对照组，而血清 NGF 水平无明显升高。抑郁严重程度与血清 BDNF 和 NGF 水平之间无相关性（p>0.05）。
本研究评估了神经营养因子在重度抑郁症发病机制中的作用。未来的研究应探讨神经营养因子与神经内分泌和遗传过程之间的关系，以阐明精神障碍的心理生物学和治疗。
