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Mechanisms of hepatoprotective effect of preparation containing superlow doses of antibodies to granulocytic colony-stimulating factor.

作者信息

Epstein O I, Zyuz'kov G N, Sotnikova N V, Stavrova L A, Fomina T I, Vetoshkina T V, Sergeeva S A, Dubskaya T Yu, Dygai A M, Gol'dberg E D

机构信息

Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.

出版信息

Bull Exp Biol Med. 2005 Nov;140(5):598-602. doi: 10.1007/s10517-006-0034-2.

DOI:10.1007/s10517-006-0034-2
PMID:16758635
Abstract

The hepatoprotective effects of superlow dose preparation of antibodies to granulocytic CSF were studied on a model of CCl4-induced hepatitis. The preparation exhibited high antiinflammatory and antisclerotic activities determined by stimulation, mobilization, and determined homing of mesenchymal stem cells into damaged liver with subsequent differentiation of these cells into mature hepatocytes.

摘要

相似文献

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