Dygai A M, Zhdanov V V, Zyuzkov G N, Stavrova L A, Miroshnichenko L A, Udut E V, Khrichkova T Yu, Simanina E V, Artamonov A V, Bekarev A A, Madonov P G, Kinsht D N, Gurto R V, Chaikovskiy A V, Markova T S, Fomina T I, Ermolaeva L A, Vetoshkina T V, Dubskaya T Yu
Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.
Bull Exp Biol Med. 2012 May;153(1):129-33. doi: 10.1007/s10517-012-1660-5.
High hepatoprotective activity of granulocytic CSF and hyaluronidase immobilized using electron-beam immobilization technology was demonstrated on the model of CCl(4)-induced hepatitis: the preparations produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects developed against the background of stimulation of bone marrow multipotent precursor cells and their mobilization into circulation accompanied by an increase in the content of parenchymatous progenitor cells in the liver. The most pronounced positive effect was observed in combined treatment with the test preparations.
在四氯化碳诱导的肝炎模型上证实了采用电子束固定技术固定的粒细胞集落刺激因子（granulocytic CSF）和透明质酸酶具有高度的肝保护活性：这些制剂产生了抗胆汁淤积、抗炎和抗硬化作用。这些作用是在骨髓多能前体细胞受到刺激并动员进入循环的背景下产生的，同时肝脏实质祖细胞的含量增加。在与测试制剂联合治疗中观察到最明显的积极效果。
