Zyuz'kov G N, Suslov N I, Dygai A M, Zhdanov V V, Gol'dberg E D
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Bull Exp Biol Med. 2005 Nov;140(5):606-11. doi: 10.1007/s10517-006-0036-0.
The role of regional cerebral neural precursor cells in restoration of the CNS activity during the development of hypoxic encephalopathy and the participation of the bone marrow mesenchymal stem cells in the formation of blood system reactions in hypoxia are shown. The mechanisms of neuroprotective effect of granulocytic colony-stimulating factor in severe oxygen insufficiency are studied. The specific psychopharmacological effect of granulocytic colony-stimulating factor is due to mobilization and determined homing of the bone marrow mesenchymal stem cells in damaged CNS zones with subsequent differentiation of these cells into specialized elements and due to activation of erythropoiesis.
研究显示了局部脑神经前体细胞在缺氧性脑病发展过程中对中枢神经系统活动恢复的作用，以及骨髓间充质干细胞在缺氧时血液系统反应形成中的参与。研究了粒细胞集落刺激因子在严重氧不足时的神经保护作用机制。粒细胞集落刺激因子的特定心理药理学作用归因于骨髓间充质干细胞的动员和定向归巢至受损的中枢神经系统区域，随后这些细胞分化为特殊成分，还归因于红细胞生成的激活。
