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Acute exposure to cadmium causes time-dependent liver injury in rats.

作者信息

Theocharis S, Margeli A, Fasitsas C, Loizidou M, Deliconstantinos G

机构信息

Department of Experimental Physiology, School of Medicine, University of Athens, Greece.

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;99(1-2):127-30. doi: 10.1016/0742-8413(91)90087-a.

DOI:10.1016/0742-8413(91)90087-a
PMID:1675962
Abstract
  1. Serum enzymes activities of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT), after intraperitoneal injection of CdCl2 showed a maximum increase at 12 hours, contrary to the alkaline phosphatase (ALP) that showed a permanent decrease by that time. 2. Cadmium concentration in liver showed an increase at 6 and 12 hours, a decrease at 18, and a re-establishment to the initial values at 24 hours. 3. Liver microsomal membrane fluidity showed an increase at 6 hours followed by a decrease within 24 hours. Free radical generation was decreasing gradually up to 24 hours. 4. Gradually increasing changes were observed from the histological study.
摘要

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