兔血清中存在的一种针对漏斗网蜘蛛（Atrax robustus）致命毒液的内源性抗毒素。

An endogenous antitoxin to the lethal venom of the funnel web spider, Atrax robustus, in rabbit sera.

Sheumack D D, Comis A, Claassens R, Mylecharane E J, Spence I, Howden M E

School of Chemistry, Macquarie University, North Ryde, NSW.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;99(1-2):157-61. doi: 10.1016/0742-8413(91)90093-9.

Abstract

An endogenous antitoxin fraction was isolated from non-immune rabbit sera by affinity chromatography with robustoxin bound to the solid support. 2. Robustoxin is the sole lethal toxin in the venom of the male funnel web spider, Atrax robustus. 3. The fraction was found to contain IgG and IgM immunoglobulins. 4. This fraction prevented or reversed the lethal actions of the crude venom in newborn mice, in mouse phrenic nerve-hemidiaphragm preparations, and in anaesthetized monkeys. 5. The antitoxin fraction is of potential value in the therapy of human envenomation by A. robustus.

摘要

通过将粗毒素结合到固相载体上进行亲和层析，从非免疫兔血清中分离出一种内源性抗毒素组分。2. 粗毒素是雄性漏斗网蜘蛛（Atrax robustus）毒液中唯一的致死毒素。3. 发现该组分含有IgG和IgM免疫球蛋白。4. 该组分在新生小鼠、小鼠膈神经-半膈肌标本以及麻醉的猴子中可预防或逆转粗毒液的致死作用。5. 该抗毒素组分在治疗人类被粗螯蛛咬伤中毒方面具有潜在价值。