Wiegratz Inka, Mittmann Katrin, Dietrich Horst, Zimmermann Thomas, Kuhl Herbert
Department of Obstetrics and Gynecology, J. W. Goethe University, Frankfurt am Main, Germany.
Fertil Steril. 2006 Jun;85(6):1812-9. doi: 10.1016/j.fertnstert.2005.11.052.
To examine the conception rate after cessation of a combination of 30 microg ethinyl E2 and 2 mg dienogest (EE/DNG).
Prospective observational study.
Population-based cohort in Germany.
PATIENT(S): Women who wished to become pregnant after cessation of an oral contraceptive (EE/DNG).
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Cumulative conception rate within 1 year after termination of EE/DNG and time to pregnancy.
RESULT(S): After 1 year of follow-up, the cumulative pregnancy rate was 86.6% (full analysis set; n = 706). When all participants with complete data were analyzed (n = 652), the cumulative pregnancy rate was 94.0%. More than 15% of the patients conceived in each of the first three cycles after termination of EE/DNG; the mean time to pregnancy was 3.5 cycles. The preceding duration of treatment with EE/DNG did not influence the conception rate. Except in the youngest age group (16-18 years), a certain delay was observed in the other age groups.
CONCLUSION(S): The present prospective study revealed only a slight delay in regaining fertility during the first three cycles after cessation of EE/DNG. Thereafter, the cumulative rate of conception did not differ from that observed in fertile women who attempted to become pregnant without prior contraception.
研究30微克炔雌醇E2与2毫克地诺孕素（EE/DNG）联合用药停药后的受孕率。
前瞻性观察研究。
德国基于人群的队列研究。
口服避孕药（EE/DNG）停药后希望怀孕的女性。
无。
EE/DNG停药后1年内的累积受孕率及受孕时间。
随访1年后，累积妊娠率为86.6%（全分析集；n = 706）。对所有有完整数据的参与者进行分析（n = 652）时，累积妊娠率为94.0%。超过15%的患者在EE/DNG停药后的前三个周期内受孕；平均受孕时间为3.5个周期。之前使用EE/DNG的治疗时长不影响受孕率。除最年轻年龄组（16 - 18岁）外，其他年龄组均观察到一定延迟。
本前瞻性研究显示，EE/DNG停药后的前三个周期内恢复生育能力仅有轻微延迟。此后，累积受孕率与未事先避孕而试图怀孕的育龄妇女的受孕率无差异。
