Pilch Paul F, Bergenhem Nils
Department of Biochemistry, Boston University School of Medicine, 80 E. Concord St., Boston, MA 02118, USA.
Mol Pharmacol. 2006 Sep;70(3):779-85. doi: 10.1124/mol.106.026104. Epub 2006 Jun 7.
Obesity is now recognized as a rapidly increasing worldwide threat to health, largely as a result of causing diabetes. Thus, considerable efforts are underway in the pharmaceutical industry to find drugs to treat this condition. Target validation in various academic and industrial laboratories has revealed a number of potential molecular targets in fat cells or adipocytes. By definition, obesity is too much fat, and we here review efforts to treat obesity and, by proxy, diabetes by modulating the metabolic state of adipocytes.
肥胖如今被公认为是一种在全球范围内迅速增长的对健康的威胁，这在很大程度上是由其导致糖尿病所致。因此，制药行业正在付出巨大努力来寻找治疗这种疾病的药物。各个学术和工业实验室的靶点验证已经揭示了脂肪细胞或脂肪组织中的一些潜在分子靶点。根据定义，肥胖就是脂肪过多，在此我们综述通过调节脂肪细胞的代谢状态来治疗肥胖以及进而治疗糖尿病的相关研究进展。
