Sheng Yao, Zhao Changhui, Zheng Shujuan, Mei Xiaohong, Huang Kunlun, Wang Guoyi, He Xiaoyun
Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science and Nutritional Engineering China Agricultural University Beijing China.
Department of Food Quality and Safety College of Food Science and Engineering Jilin University Changchun China.
Food Sci Nutr. 2019 Mar 5;7(4):1295-1301. doi: 10.1002/fsn3.962. eCollection 2019 Apr.
Obesity has become one of the most important health problems worldwide requiring urgent need for efficient control. ()-a type of edible mushroom with abundant bioactive molecules-is a promising source for achieving this goal. In the present study, we evaluated the anti-obesity and hypolipidemic effect of water extract (PWE) using a series of biochemical assays in randomized high-fat diet-induced obese (DIO) C57BL/6J mice, which were gavaged daily with low or high levels of PWE (400 or 800 mg/kg of body weight, respectively) in addition to high-fat diet for 12 weeks. Results showed that PWE significantly reduced the weight gain, fat accumulation, and food intake of DIO mice within 12 weeks. PWE also decreased the serum triglycerides, cholesterol and low-density lipoprotein, aspartate transaminase, nonesterified fatty acid, and creatinine, but increased high-density lipoprotein. Additionally, PWE improved the glucose tolerance of mice fed with high fat. From above, we conclude that PWE has great potential as functional foods for management of obesity and/or associated metabolic disorders.
肥胖已成为全球最重要的健康问题之一，亟需有效控制。平菇——一种含有丰富生物活性分子的食用菌——是实现这一目标的一个有前景的来源。在本研究中，我们使用一系列生化分析方法，对随机高脂饮食诱导的肥胖（DIO）C57BL/6J小鼠进行实验，评估了平菇水提取物（PWE）的抗肥胖和降血脂作用。除高脂饮食外，这些小鼠每天分别灌胃低剂量或高剂量的PWE（分别为400或800毫克/千克体重），持续12周。结果显示，PWE在12周内显著降低了DIO小鼠的体重增加、脂肪堆积和食物摄入量。PWE还降低了血清甘油三酯、胆固醇、低密度脂蛋白、天冬氨酸转氨酶、非酯化脂肪酸和肌酐，但提高了高密度脂蛋白。此外，PWE改善了高脂喂养小鼠的葡萄糖耐量。综上所述，我们得出结论，PWE作为管理肥胖和/或相关代谢紊乱的功能性食品具有巨大潜力。
