Mundo J, Peris P, Monegal A, Navasa M, Cervera R, Guañiabens N
Service of Rheumatology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain.
Lupus. 2006;15(5):304-7. doi: 10.1191/0961203306lu2301cr.
We describe the case of a 31-year-old man who presented with an antiphospholipid syndrome (APS), which manifested as multifocal avascular necrosis (AVN) one year after orthotopic liver transplantation. The patient developed multiple AVN affecting hips, left knee, humerus and tarsal bones just after withdrawal of corticosteroid therapy. Three years later when lupus anticoagulant was detected, he began anticoagulant treatment and no further AVN episodes were observed. It is important to be aware of this clinical manifestation of APS, especially in these cases where it can be easily overlooked because of corticosteroid therapy.
我们描述了一名31岁男性的病例，该患者患有抗磷脂综合征（APS），在原位肝移植一年后表现为多灶性无血管性坏死（AVN）。患者在停用皮质类固醇治疗后不久就出现了影响髋部、左膝、肱骨和跗骨的多处AVN。三年后检测到狼疮抗凝物时，他开始接受抗凝治疗，此后未再观察到AVN发作。认识到APS的这种临床表现很重要，尤其是在因皮质类固醇治疗而容易被忽视的情况下。
