State Key Laboratory of Oral Diseases, National Center of Stomatology, National Clinical Research Center for Oral Diseases, Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Department of Oral Medicine, Qingdao Stomatological Hospital, Qingdao 266001, China.
Int J Environ Res Public Health. 2022 Oct 23;19(21):13787. doi: 10.3390/ijerph192113787.
This study is the first time to assess the synergistic efficacy and safety of plaque control on erosive non-gingival oral lichen planus (OLP). A randomized, controlled, clinical trial with blind evaluation was designed, and 48 OLP patients with erosive non-gingival OLP lesions were randomly assigned to the experimental group ( = 25, receiving intralesional triamcinolone acetonide injection, periodontal scaling, and oral hygiene instruction) and the control group ( = 23, only receiving intralesional triamcinolone acetonide injection) once a week for 2 weeks. Erosion size, pain level, plaque index, and community periodontal index were measured at every visit. Patients cured of erosion were followed up for 3 months to evaluate the recurrence rate. Adverse reactions were also recorded. At day 14 ± 2, the experimental group showed a higher completely healed percentage of erosion, a greater reduction of erosion size and pain level. However, no significant difference was observed in the recurrence rate. No participants had any severe adverse reactions. In conclusion, an improvement was observed in patients with plaque control, and future studies with larger sample sizes are needed to reinforce the external validity of this study.
本研究首次评估了斑块控制对糜烂型非牙龈口腔扁平苔藓（OLP）的协同疗效和安全性。设计了一项随机、对照、盲法评估的临床试验，将 48 例糜烂型非牙龈 OLP 病变患者随机分为实验组（n=25，接受皮损内曲安奈德注射、牙周洁治和口腔卫生指导）和对照组（n=23，仅接受皮损内曲安奈德注射），每周一次，共 2 周。每次就诊时测量侵蚀大小、疼痛程度、菌斑指数和社区牙周指数。治愈侵蚀的患者随访 3 个月以评估复发率。还记录了不良反应。在第 14 ± 2 天，实验组显示出更高的完全愈合百分比的侵蚀，更大的侵蚀大小和疼痛程度的减少。然而，复发率没有显著差异。没有参与者有任何严重的不良反应。总之，斑块控制改善了患者的状况，但需要更大样本量的研究来增强本研究的外部有效性。
