Department of Oral Medicine, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Clin Exp Dent Res. 2022 Jun;8(3):707-714. doi: 10.1002/cre2.550. Epub 2022 Feb 26.
To evaluate the clinical efficacy of intralesional platelet-rich plasma (PRP) injections compared to intralesional triamcinolone acetonide (TA) injections in the treatment of erosive oral lichen planus (EOLP).
Twenty patients with EOLP were assigned randomly to either PRP or TA group. Patients received weekly intralesional injections for 4 weeks, and then followed up for 3 months on regular visits every 2 weeks. Pain scores using numerical pain score and clinical score were recorded by a blinded assessor each visit for all patients and remission score at the end of the trial was recorded.
Both groups showed significant improvement in the clinical parameters (pain and clinical score) "p = .001." Regarding remission of the lesions, 80% of patients in the PRP group showed complete remission compared to 70% in the TA group. However, there is no statistical significance when comparing the two groups in pain score, clinical score, or remission.
PRP injections could be considered as an effective alternative single treatment modality for EOLP. The protocol for this study registered in Clinicaltrials.gov registry under the identifier number: NCT03293368.
评估病灶内注射富血小板血浆（PRP）与病灶内注射曲安奈德（TA）治疗糜烂型口腔扁平苔藓（EOLP）的临床疗效。
将 20 例 EOLP 患者随机分为 PRP 组或 TA 组。患者每周接受病灶内注射治疗 4 周，然后每 2 周定期随访 3 个月。所有患者由盲法评估者在每次就诊时记录疼痛评分（数字疼痛评分）和临床评分，在试验结束时记录缓解评分。
两组患者的临床参数（疼痛和临床评分）均有显著改善（p=0.001）。在病变缓解方面，PRP 组 80%的患者完全缓解，而 TA 组为 70%。然而，两组间疼痛评分、临床评分或缓解率的比较无统计学意义。
PRP 注射可被视为 EOLP 的一种有效替代单一治疗方法。本研究方案已在 Clinicaltrials.gov 注册，注册号为：NCT03293368。
