Sallese Michele, Pulvirenti Teodoro, Luini Alberto
Laboratory of Membrane Traffic, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy.
EMBO J. 2006 Jun 21;25(12):2663-73. doi: 10.1038/sj.emboj.7601172. Epub 2006 Jun 8.
Some of the important open questions concerning the physiology of the secretory pathway relate to its homeostasis. Secretion involves a number of separate compartments for which their transport activities should be precisely cross-coordinated to avoid gross imbalances in the trafficking system. Moreover, the membrane fluxes across these compartments should be able to adapt to environmental 'requests' and to respond to extracellular signals. How is this regulation effected? Here, we consider evidence that endomembrane-based signalling cascades that are similar in organization to those used at the plasma membrane coordinate membrane traffic. If this is the case, this would also represent a model for a more general inter-organelle signalling network for functionally interconnecting different intracellular activities, a necessity for the maintenance of cellular homeostasis and to express harmonic global cellular responses.
一些关于分泌途径生理学的重要开放性问题涉及其内稳态。分泌过程涉及多个独立的区室，其转运活动应精确地相互协调，以避免转运系统出现严重失衡。此外，跨这些区室的膜通量应能够适应环境“需求”并对细胞外信号作出反应。这种调节是如何实现的呢？在这里，我们考虑这样的证据：基于内膜的信号级联反应在组织上与质膜上使用的信号级联反应相似，可协调膜运输。如果是这样的话，这也将代表一个更普遍的细胞器间信号网络模型，用于在功能上连接不同的细胞内活动，这是维持细胞内稳态和表达协调一致的整体细胞反应所必需的。
