[代谢综合征患者血浆血管性血友病因子（vWF）和一氧化氮（NO）水平及其与代谢紊乱的关系]

[Plasma levels of vWF and NO in patients with metabolic syndrome and their relationship with metabolic disorders].

作者信息

Sun Ya-xun, Hu Shen-jiang, Zhang Xin-hua, Sun Jian, Zhu Chao-hui, Zhang Zhi-jie

机构信息

Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

出版信息

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 May;35(3):315-8. doi: 10.3785/j.issn.1008-9292.2006.03.015.

DOI:10.3785/j.issn.1008-9292.2006.03.015

PMID:16764036

Abstract

OBJECTIVE

To measure the plasma levels of von Willebrand factor (vWF) and nitric oxide (NO) in patients with metabolic disorders and to study their relationships with the disease.

METHODS

The plasma levels of vWF and NO were determined in patients with metabolic syndrome (MS group, n=36), patients with 1 - 2 metabolic disorders (MD group, n=43) and normal subjects (control group, n=30).

RESULT

The plasma vWF level was higher in MS group than that in MD group (P <0.05) and in control group (P <0.001); the vWF level in MD group was higher than that in control group (P <0.05). The NO level was lower in MS group and in MD group than that in control group (both P<0.05), while the difference between MS and MD groups was not statistically significant (P >0.05). Multiple stepwise regression showed that vWF level was correlated with systolic BP (SBP), diastolic BP(DBP) and pulse BP; that NO level was correlated with BMI, SBP and TG.

CONCLUSION

Multiple metabolic disorders of metabolic syndrome may injure endothelial cells, and the degree of endothelial cell injury seems to be correlated with the BMI, SBP, DBP, pulse BP and TG.

摘要

目的

检测代谢紊乱患者血浆血管性血友病因子（vWF）和一氧化氮（NO）水平，并研究其与疾病的关系。

方法

测定代谢综合征患者（MS组，n = 36）、患有1 - 2种代谢紊乱的患者（MD组，n = 43）和正常受试者（对照组，n = 30）的血浆vWF和NO水平。

结果

MS组血浆vWF水平高于MD组（P <0.05）和对照组（P <0.001）；MD组vWF水平高于对照组（P <0.05）。MS组和MD组的NO水平均低于对照组（均为P<0.05），而MS组与MD组之间的差异无统计学意义（P >0.05）。多元逐步回归显示，vWF水平与收缩压（SBP）、舒张压（DBP）和脉压相关；NO水平与体重指数（BMI）、SBP和甘油三酯（TG）相关。